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https://ahro.austin.org.au/austinjspui/handle/1/12756
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ebert, Gregor | - |
dc.contributor.author | Preston, Simon | - |
dc.contributor.author | Allison, Cody | - |
dc.contributor.author | Cooney, James | - |
dc.contributor.author | Toe, Jesse G | - |
dc.contributor.author | Stutz, Michael D | - |
dc.contributor.author | Ojaimi, Samar | - |
dc.contributor.author | Scott, Hamish W | - |
dc.contributor.author | Baschuk, Nikola | - |
dc.contributor.author | Nachbur, Ueli | - |
dc.contributor.author | Torresi, Joseph | - |
dc.contributor.author | Chin, Ruth | - |
dc.contributor.author | Colledge, Danielle | - |
dc.contributor.author | Li, Xin | - |
dc.contributor.author | Warner, Nadia | - |
dc.contributor.author | Revill, Peter | - |
dc.contributor.author | Bowden, Scott | - |
dc.contributor.author | Silke, John | - |
dc.contributor.author | Begley, C Glenn | - |
dc.contributor.author | Pellegrini, Marc | - |
dc.date.accessioned | 2015-05-16T02:29:38Z | |
dc.date.available | 2015-05-16T02:29:38Z | |
dc.date.issued | 2015-04-20 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America 2015; 112(18): 5797-802 | en_US |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/12756 | en |
dc.description.abstract | Hepatitis B virus (HBV) infection can result in a spectrum of outcomes from immune-mediated control to disease progression, cirrhosis, and liver cancer. The host molecular pathways that influence and contribute to these outcomes need to be defined. Using an immunocompetent mouse model of chronic HBV infection, we identified some of the host cellular and molecular factors that impact on infection outcomes. Here, we show that cellular inhibitor of apoptosis proteins (cIAPs) attenuate TNF signaling during hepatitis B infection, and they restrict the death of infected hepatocytes, thus allowing viral persistence. Animals with a liver-specific cIAP1 and total cIAP2 deficiency efficiently control HBV infection compared with WT mice. This phenotype was partly recapitulated in mice that were deficient in cIAP2 alone. These results indicate that antagonizing the function of cIAPs may promote the clearance of HBV infection. | en_US |
dc.language.iso | en | en |
dc.subject.other | TNF | en |
dc.subject.other | cIAP1 | en |
dc.subject.other | cIAP2 | en |
dc.subject.other | cellular inhibitor of apoptosis proteins | en |
dc.subject.other | hepatitis B virus | en |
dc.title | Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | en_US |
dc.identifier.affiliation | Division of Infection and Immunity and Cell Signaling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | en_US |
dc.identifier.affiliation | Faculty of Science Technology and Engineering, School of Molecular Sciences, Department of Biochemistry, LaTrobe Institute for Molecular Science, Bundoora, VIC 3086, Australia | en_US |
dc.identifier.affiliation | Infectious Diseases | en_US |
dc.identifier.affiliation | Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute, Melbourne, VIC 3000, Australia | en_US |
dc.identifier.affiliation | Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia | en_US |
dc.identifier.affiliation | Research and Development Division, TetraLogic Pharmaceuticals Corporation, Inc., Malvern, PA 19355. | en_US |
dc.identifier.affiliation | Medicine (University of Melbourne) | en_US |
dc.identifier.doi | 10.1073/pnas.1502390112 | en_US |
dc.description.pages | 5797-802 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/25902529 | en |
dc.type.content | Text | en_US |
dc.type.austin | Journal Article | en |
local.name.researcher | Torresi, Joseph | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Infectious Diseases | - |
Appears in Collections: | Journal articles |
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