Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12730
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dc.contributor.authorAybek, Selmaen
dc.contributor.authorNicholson, Timothy Ren
dc.contributor.authorO'Daly, Owenen
dc.contributor.authorZelaya, Fernandoen
dc.contributor.authorKanaan, Richard A Aen
dc.contributor.authorDavid, Anthony Sen
dc.date.accessioned2015-05-16T02:27:44Z
dc.date.available2015-05-16T02:27:44Z
dc.date.issued2015-04-10en
dc.identifier.citationPLoS One 2015; 10(4): e0123273en
dc.identifier.govdoc25859660en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12730en
dc.description.abstractTo evaluate the neural correlates of implicit processing of negative emotions in motor conversion disorder (CD) patients.An event related fMRI task was completed by 12 motor CD patients and 14 matched healthy controls using standardised stimuli of faces with fearful and sad emotional expressions in comparison to faces with neutral expressions. Temporal changes in the sensitivity to stimuli were also modelled and tested in the two groups.We found increased amygdala activation to negative emotions in CD compared to healthy controls in region of interest analyses, which persisted over time consistent with previous findings using emotional paradigms. Furthermore during whole brain analyses we found significantly increased activation in CD patients in areas involved in the 'freeze response' to fear (periaqueductal grey matter), and areas involved in self-awareness and motor control (cingulate gyrus and supplementary motor area).In contrast to healthy controls, CD patients exhibited increased response amplitude to fearful stimuli over time, suggesting abnormal emotional regulation (failure of habituation / sensitization). Patients with CD also activated midbrain and frontal structures that could reflect an abnormal behavioral-motor response to negative including threatening stimuli. This suggests a mechanism linking emotions to motor dysfunction in CD.en
dc.language.isoenen
dc.titleEmotion-motion interactions in conversion disorder: an FMRI study.en
dc.typeJournal Articleen
dc.identifier.journaltitlePLoS Oneen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin Health, Heidelberg, VIC, 3084, Australiaen
dc.identifier.affiliationSection of Cognitive Neuropsychiatry, King's College London, Institute of Psychiatry, London, SE5 8AF, United Kingdom; Laboratory for Behavioral Neurology and Imaging of Cognition, Fundamental Neurosciences, Geneva University, Rue Michel-Servet 1, 1211, Genève, Switzerland.en
dc.identifier.affiliationDepartment of Neuroimaging, King's College London, Institute of Psychiatry, London, SE5 8AF, United Kingdom.en
dc.identifier.affiliationSection of Cognitive Neuropsychiatry, King's College London, Institute of Psychiatry, London, SE5 8AF, United Kingdom.en
dc.identifier.doi10.1371/journal.pone.0123273en
dc.description.pagese0123273en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25859660en
dc.identifier.orcid0000-0003-0992-1917-
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptPsychiatry (University of Melbourne)-
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