Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12699
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dc.contributor.authorProwle, John Ren
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T02:25:43Z-
dc.date.available2015-05-16T02:25:43Z-
dc.date.issued2015-01-01en
dc.identifier.citationSeminars in Nephrology; 35(1): 64-74en
dc.identifier.govdoc25795500en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12699en
dc.description.abstractTraditionally, renal ischemia has been regarded as central to the pathogenesis of sepsis-associated acute kidney injury (SA-AKI). Accordingly, hemodynamic management of SA-AKI has emphasized restoration of renal perfusion, whereas, experimentally, ischemia reperfusion models have been emphasized. However, in human beings, SA-AKI usually is accompanied by hyperdynamic circulation. Moreover, clinical and experimental evidence now suggests the importance of inflammatory mechanisms in the development of AKI and microcirculatory dysfunction more than systemic alteration in renal perfusion. In this review, we examine systemic, regional, and microcirculatory hemodynamics in SA-AKI, and attempt to rationalize the hemodynamic management of this condition.en
dc.language.isoenen
dc.subject.otherAcute kidney injuryen
dc.subject.othercritical careen
dc.subject.otherhemodynamic managementen
dc.subject.othermicrocirculationen
dc.subject.otherrenal blood flowen
dc.subject.othersepsisen
dc.titleSepsis-associated acute kidney injury: macrohemodynamic and microhemodynamic alterations in the renal circulation.en
dc.typeJournal Articleen
dc.identifier.journaltitleSeminars in nephrologyen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationWilliam Harvey Research Institute, Queen Mary University of London, London, UKen
dc.identifier.affiliationAdult Critical Care Unit, Department of Renal Medicine and Transplantation, The Royal London Hospital, Barts Health NHS Trust, London, UKen
dc.identifier.doi10.1016/j.semnephrol.2015.01.007en
dc.description.pages64-74en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25795500en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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