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Title: Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies.
Austin Authors: Dingjan, Tamir;Spendlove, Ian;Durrant, Lindy G;Scott, Andrew M ;Yuriev, Elizabeth;Ramsland, Paul A 
Affiliation: Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia
Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Centre for Biomedical Research, Burnet Institute, Melbourne, VIC 3004, Australia
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, VIC 3004, Australia
Department of Surgery Austin Health, University of Melbourne, Heidelberg, VIC 3084, Australia
School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia
School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, WA 6845, Australia
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia
Academic Department of Clinical Oncology, Division of Cancer and Stem cells, University of Nottingham, City Hospital, Nottingham NG5 1PB, United Kingdom.
Issue Date: 7-Mar-2015
Publication information: Molecular Immunology 2015; 67(2 Pt A): 75-88
Abstract: Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability to engage in antibody-dependent effector mechanisms, internalize to deliver cytotoxic payloads, and display direct effects on cells by lysis or by modulating the biological pathways of their target antigens. Importantly, one of the universal changes in cancer is glycosylation and carbohydrate-binding antibodies can be produced to selectively recognize tumor cells over normal tissues. A promising group of cell surface antibody targets consists of carbohydrates presented as glycolipids or glycoproteins. In this review, we outline the basic principles of antibody-based targeting of carbohydrate antigens in cancer. We also present a detailed structural view of antibody recognition and the conformational properties of a series of related tissue-blood group (Lewis) carbohydrates that are being pursued as potential targets of cancer immunotherapy.
Gov't Doc #: 25757815
DOI: 10.1016/j.molimm.2015.02.028
Journal: Molecular immunology
Type: Journal Article
Subjects: Antibody tumor targeting
Blood group carbohydrates
Cancer immunotherapy
Carbohydrate conformations
Carbohydrate recognition
Protein–carbohydrate interactions
Appears in Collections:Journal articles

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