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dc.contributor.authorKwong, Jason C-
dc.contributor.authorMcCallum, N-
dc.contributor.authorSintchenko, V-
dc.contributor.authorHowden, Benjamin P-
dc.identifier.citationPathology; 47(3): 199-210en_US
dc.description.abstractGenomics and whole genome sequencing (WGS) have the capacity to greatly enhance knowledge and understanding of infectious diseases and clinical microbiology.The growth and availability of bench-top WGS analysers has facilitated the feasibility of genomics in clinical and public health microbiology.Given current resource and infrastructure limitations, WGS is most applicable to use in public health laboratories, reference laboratories, and hospital infection control-affiliated laboratories.As WGS represents the pinnacle for strain characterisation and epidemiological analyses, it is likely to replace traditional typing methods, resistance gene detection and other sequence-based investigations (e.g., 16S rDNA PCR) in the near future.Although genomic technologies are rapidly evolving, widespread implementation in clinical and public health microbiology laboratories is limited by the need for effective semi-automated pipelines, standardised quality control and data interpretation, bioinformatics expertise, and infrastructure.en_US
dc.titleWhole genome sequencing in clinical and public health microbiology.en_US
dc.typeJournal Articleen_US
dc.identifier.affiliationMicrobiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, the University of Melbourne, at the Doherty Institute for Infection and Immunity, Melbourne, Vicen_US
dc.identifier.affiliationMarie Bashir Institute for Infectious Diseases and Biosecurity and Sydney Medical School, The University of Sydney, Sydney, NSWen_US
dc.identifier.affiliationCentre for Infectious Diseases and Microbiology-Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Sydney, NSWen_US
dc.identifier.affiliationDepartment of Microbiology, Monash University, Clayton, Victoria, Australiaen_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.type.austinJournal Articleen, Benjamin P
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Diseases- Diseases-
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