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Title: Serum glucose and insulin levels in normotensive (WKY) and spontaneously hypertensive (SH) rats during and after the cessation of continuous (10 day) clonidine infusion.
Austin Authors: Lewis, S J;Dunlop, M;Jarrott, B
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-May-1989
Publication information: The Journal of Pharmacy and Pharmacology; 41(5): 353-5
Abstract: The concentrations of glucose were elevated whereas those of insulin were decreased in the sera of normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats on day 10 of a continuous subcutaneous infusion of clonidine (10 micrograms kg-1 h-1 for 10 days). Fifteen to 18 h after cessation of infusion, the glucose levels of both strains had fallen to below those of the respective controls whereas the insulin levels remained suppressed. As such the hypoglycaemia may be related to the general increase in metabolic requirements associated with the post-infusion 'withdrawal syndrome'.
Gov't Doc #: 2569528
Journal: The Journal of pharmacy and pharmacology
Type: Journal Article
Subjects: Animals
Blood Glucose.metabolism
Body Temperature.drug effects
Body Weight
Clonidine.administration & dosage.pharmacology
Infusions, Intravenous
Rats, Inbred SHR
Rats, Inbred WKY
Appears in Collections:Journal articles

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