Please use this identifier to cite or link to this item:
Title: The emerging role of exosomes in epithelial-mesenchymal-transition in cancer.
Austin Authors: Vella, Laura Jayne
Affiliation: Ludwig Institute for Cancer Research, Melbourne-Austin Branch, Cancer Immunobiology Laboratory, Olivia Newton-John Cancer and Wellness Centre , Heidelberg, VIC , Australia ; The Florey Institute for Neuroscience and Mental Health , Parkville, VIC , Australia
Issue Date: 19-Dec-2014
Publication information: Frontiers in Oncology 2014; 4: 361
Abstract: Metastasis in cancer consists of multiple steps, including epithelial-mesenchymal-transition (EMT), which is characterized by the loss of epithelial-like characteristics and the gain of mesenchymal-like attributes including cell migration and invasion. It is clear that the tumor microenvironment can promote the metastatic cascade and that intercellular communication is necessary for this to occur. Exosomes are small membranous vesicles secreted by most cell types into the extracellular environment and they are important communicators in the tumor microenvironment. They promote angiogenesis, invasion, and proliferation in recipient cells to support tumor growth and a prometastatic phenotype. Although it is clear that exosomes contribute to cancer cell plasticity, experimental evidence to define exosome induced plasticity as EMT is only just coming to light. This review will discuss recent research on exosomal regulation of the EMT process in the tumor microenvironment.
Gov't Doc #: 25566500
DOI: 10.3389/fonc.2014.00361
Journal: Frontiers in oncology
Type: Journal Article
Subjects: Cancer
extracellular vesicles
intercellular signaling
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Mar 30, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.