Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12485
Title: Bidirectional transport of NMDA receptor and ionophore in the vagus nerve.
Austin Authors: Cincotta, M;Beart, P M;Summers, R J;Lodge, D
Affiliation: University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 24-Jan-1989
Publication information: European Journal of Pharmacology; 160(1): 167-71
Abstract: Accumulations of binding sites for [3H]3-[+-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic ([3H]CPP) and [3H]-N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) were demonstrated both proximal and distal to 24-h ligatures of the central and peripheral vagus nerve in the rat using radioligand binding and autoradiography. Peaks of label occurred at the proximal and distal extremities of double ligations but not between the ligatures, or in sham-operated or colchicine-treated nerves. Together these results suggest that both the primary acceptor site and the ionophore of the N-methyl-D-aspartate receptor undergo bidirectional axonal transport in central and peripheral branches of the vagus nerve.
Gov't Doc #: 2540989
URI: http://ahro.austin.org.au/austinjspui/handle/1/12485
URL: https://pubmed.ncbi.nlm.nih.gov/2540989
Type: Journal Article
Subjects: Animals
Anticonvulsants.metabolism.toxicity
Autoradiography
Ionophores.metabolism
Male
Phencyclidine.analogs & derivatives.metabolism.toxicity
Piperazines.metabolism.toxicity
Rats
Rats, Inbred Strains
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter.metabolism
Vagus Nerve.metabolism
Appears in Collections:Journal articles

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