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Title: Plasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase.
Austin Authors: Phillips, P A;Sasadeus, J;Hodsman, G P;Horowitz, J D;Saltups, A;Johnston, Colin I
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Feb-1989
Publication information: British Heart Journal; 61(2): 139-43
Abstract: Plasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM] were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase.
Gov't Doc #: 2522310
Journal: British heart journal
Type: Journal Article
Subjects: Angina Pectoris.blood
Atrial Natriuretic Factor.blood
Chest Pain.blood
Middle Aged
Myocardial Infarction.blood.drug therapy
Streptokinase.therapeutic use
Appears in Collections:Journal articles

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