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dc.contributor.authorKao, Yung Hsiangen
dc.contributor.authorMagsombol, Butch Men
dc.contributor.authorToh, Yingen
dc.contributor.authorTay, Kiang Hiongen
dc.contributor.authorChow, Pierce Khen
dc.contributor.authorGoh, Anthony Swen
dc.contributor.authorNg, David Ceen
dc.identifier.citationEjnmmi Research 2014; 4(): 33en
dc.description.abstractFor yttrium-90 ((90)Y) radioembolization, the common practice of assuming a standard 1,000-g lung mass for predictive dosimetry is fundamentally incongruent with the modern philosophy of personalized medicine. We recently developed a technique of personalized predictive lung dosimetry using technetium-99m ((99m)Tc) macroaggregated albumin (MAA) single photon emission computed tomography with integrated CT (SPECT/CT) of the lung as part of our routine dosimetric protocol for (90)Y radioembolization. Its rationales are the technical superiority of SPECT/CT over planar scintigraphy, ease and convenience of lung auto-segmentation CT densitovolumetry, and dosimetric advantage of patient-specific lung parenchyma masses.This is a retrospective study of our pulmonary clinical outcomes and comparison of lung dosimetric accuracy and precision by (99m)Tc MAA SPECT/CT versus conventional planar methodology. (90)Y resin microspheres (SIR-Spheres) were used for radioembolization. Diagnostic CT densitovolumetry was used as a reference for lung parenchyma mass. Pulmonary outcomes were based on follow-up diagnostic CT chest or X-ray.Thirty patients were analyzed. The mean lung parenchyma mass of our Southeast Asian cohort was 822 ± 103 g standard deviation (95% confidence interval 785 to 859 g). Patient-specific lung parenchyma mass estimation by CT densitovolumetry on (99m)Tc MAA SPECT/CT is accurate (bias -21.7 g) and moderately precise (95% limits of agreement -194.6 to +151.2 g). Lung mean radiation absorbed doses calculated by (99m)Tc MAA SPECT/CT and planar methodology are both accurate (bias <0.5 Gy), but (99m)Tc MAA SPECT/CT offers better precision over planar methodology (95% limits of agreement -1.76 to +2.40 Gy versus -3.48 to +3.31 Gy, respectively). None developed radiomicrosphere pneumonitis when treated up to a lung mean radiation absorbed dose of 18 Gy at a median follow-up of 4.4 months.Personalized predictive lung dosimetry by (99m)Tc MAA SPECT/CT is clinically feasible, safe, and more precise than conventional planar methodology for (90)Y radioembolization radiation planning.en
dc.subject.otherCT lung densitovolumetryen
dc.subject.otherLung massen
dc.subject.otherPartition modelen
dc.subject.otherSelective internal radiation therapyen
dc.subject.otherTechnetium-99m macroaggregated albumin SPECT/CTen
dc.subject.otherYttrium-90 radioembolizationen
dc.titlePersonalized predictive lung dosimetry by technetium-99m macroaggregated albumin SPECT/CT for yttrium-90 radioembolization.en
dc.typeJournal Articleen
dc.identifier.journaltitleEJNMMI researchen
dc.identifier.affiliationDepartment of Nuclear Medicine and PET, Singapore General Hospital, Outram Road, Singapore 169608, Singapore ; Department of Nuclear Medicine, Austin Hospital, Level 1, Harold Stokes Building, 145 Studley Rd, Melbourne 3084, Victoria, Australiaen
dc.identifier.affiliationDepartment of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.en
dc.identifier.affiliationDepartment of General Surgery, Singapore General Hospital, Outram Road, Singapore 169608, Singapore ; Department of Surgical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore ; Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, 8 College Rd, Singapore 169857, Singapore.en
dc.identifier.affiliationDepartment of Nuclear Medicine and PET, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.en
dc.type.austinJournal Articleen
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item.openairetypeJournal Article-
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