Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12234
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dc.contributor.authorZhu, Xiaolinen
dc.contributor.authorNeed, Anna Cen
dc.contributor.authorPetrovski, Slavéen
dc.contributor.authorGoldstein, David Ben
dc.date.accessioned2015-05-16T01:53:31Z
dc.date.available2015-05-16T01:53:31Z
dc.date.issued2014-05-27en
dc.identifier.citationNature Neuroscience 2014; 17(6): 773-81en
dc.identifier.govdoc24866043en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12234en
dc.description.abstractRecent human genetic studies have consistently shown that mutations in the same gene or same genomic region can increase the risk of a broad range of complex neuropsychiatric disorders. Despite the steadily increasing number of examples of such nonspecific effects on risk, the underlying biological causes remain mysterious. Here we investigate the phenomenon of such nonspecific risk by identifying Mendelian disease genes that are associated with multiple diseases and explore what is known about the underlying mechanisms in these more 'simple' examples. Our analyses make clear that there are a variety of mechanisms at work, emphasizing how challenging it will be to elucidate the causes of nonspecific risk in complex disease. Ultimately, we conclude that functional approaches will be critical for explaining the causes of nonspecific risk factors discovered by human genetic studies of neuropsychiatric disorders.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherGenetic Predisposition to Disease.geneticsen
dc.subject.otherHumansen
dc.subject.otherMendelian Randomization Analysis.methods.trendsen
dc.subject.otherMental Disorders.diagnosis.geneticsen
dc.subject.otherMutation.geneticsen
dc.titleOne gene, many neuropsychiatric disorders: lessons from Mendelian diseases.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature neuroscienceen
dc.identifier.affiliationCenter for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USAen
dc.identifier.affiliationDepartment of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDivision of Brain Sciences, Department of Medicine, Imperial College London, London, UKen
dc.identifier.doi10.1038/nn.3713en
dc.description.pages773-81en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24866043en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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