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Title: Effect of voxel size when calculating patient specific radionuclide dosimetry estimates using direct Monte Carlo simulation.
Austin Authors: Hickson, Kevin J;O'Keefe, Graeme J
Affiliation: Centre for PET, Austin Health, Studley Rd, Heidelberg, VIC, 3084, Australia,
Issue Date: 25-May-2014
Publication information: Australasian Physical & Engineering Sciences in Medicine / Supported By the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine 2014; 37(3): 495-503
Abstract: The scalable XCAT voxelised phantom was used with the GATE Monte Carlo toolkit to investigate the effect of voxel size on dosimetry estimates of internally distributed radionuclide calculated using direct Monte Carlo simulation. A uniformly distributed Fluorine-18 source was simulated in the Kidneys of the XCAT phantom with the organ self dose (kidney ← kidney) and organ cross dose (liver ← kidney) being calculated for a number of organ and voxel sizes. Patient specific dose factors (DF) from a clinically acquired FDG PET/CT study have also been calculated for kidney self dose and liver ← kidney cross dose. Using the XCAT phantom it was found that significantly small voxel sizes are required to achieve accurate calculation of organ self dose. It has also been used to show that a voxel size of 2 mm or less is suitable for accurate calculations of organ cross dose. To compensate for insufficient voxel sampling a correction factor is proposed. This correction factor is applied to the patient specific dose factors calculated with the native voxel size of the PET/CT study.
Gov't Doc #: 24859803
DOI: 10.1007/s13246-014-0277-6
Type: Journal Article
Subjects: Computer Simulation
Dose-Response Relationship, Radiation
Fluorodeoxyglucose F18.diagnostic use
Kidney.radiography.radionuclide imaging
Monte Carlo Method
Phantoms, Imaging
Radiographic Image Interpretation, Computer-Assisted
Appears in Collections:Journal articles

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