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DC Field | Value | Language |
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dc.contributor.author | Branford, Susan | en |
dc.contributor.author | Yeung, David T | en |
dc.contributor.author | Parker, Wendy T | en |
dc.contributor.author | Roberts, Nicola D | en |
dc.contributor.author | Purins, Leanne | en |
dc.contributor.author | Braley, Jodi A | en |
dc.contributor.author | Altamura, Haley K | en |
dc.contributor.author | Yeoman, Alexandra L | en |
dc.contributor.author | Georgievski, Jasmina | en |
dc.contributor.author | Jamison, Bronte A | en |
dc.contributor.author | Phillis, Stuart | en |
dc.contributor.author | Donaldson, Zoe | en |
dc.contributor.author | Leong, Mary | en |
dc.contributor.author | Fletcher, Linda | en |
dc.contributor.author | Seymour, John F | en |
dc.contributor.author | Grigg, Andrew P | en |
dc.contributor.author | Ross, David M | en |
dc.contributor.author | Hughes, Timothy P | en |
dc.date.accessioned | 2015-05-16T01:53:04Z | |
dc.date.available | 2015-05-16T01:53:04Z | |
dc.date.issued | 2014-05-23 | en |
dc.identifier.citation | Blood 2014; 124(4): 511-8 | en |
dc.identifier.govdoc | 24859364 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/12227 | en |
dc.description.abstract | In chronic myeloid leukemia (CML) patients, a breakpoint cluster region-Abelson (BCR-ABL1) value >10% at 3 months of therapy is statistically associated with poorer outcome, yet many of these patients still achieve satisfactory outcomes. We investigated 528 first-line imatinib-treated patients to determine whether patients with the poorest outcome can be better discriminated at 3 months. All outcomes were significantly superior for the 410 patients with BCR-ABL1 ≤10% at 3 months (P < .001). However, the poorest outcomes among the 95 evaluable patients with BCR-ABL1 >10% at 3 months were identified by the rate of BCR-ABL1 decline from baseline, assessed by estimating the number of days over which BCR-ABL1 halved. Patients with BCR-ABL1 halving time <76 days (n = 74) had significantly superior outcomes compared with patients whose BCR-ABL1 values did not halve by 76 days (n = 21; 4-year overall survival, 95% vs 58%, P = .0002; progression-free survival, 92% vs 63%, P = .008; failure-free survival, 59% vs 6%, P < .0001; and major molecular response, 54% vs 5%, P = .008). By multivariate analysis, the halving time was an independent predictor of outcome in this poor risk group. Our study highlighted that the rate of BCR-ABL1 decline may be a critical prognostic discriminator of the patients with very poor outcome among those >10% at 3 months. The International Randomized IFN vs STI571 (IRIS) trial was registered at http://www.clinicaltrials.gov as #NCT00006343. The Tyrosine Kinase Inhibitor Optimization and Selectivity (TOPS) trial was registered at http://www.clinicaltrials.gov as #NCT00124748. The Therapeutic Intensification in DE-novo Leukaemia (TIDEL) I trial was registered at http://www.ANZCTR.org.au as #ACTRN12607000614493. The TIDEL II trial was registered at http://www.ANZCTR.org.au as #ACTRN12607000325404. | en |
dc.language.iso | en | en |
dc.subject.other | Antineoplastic Agents.therapeutic use | en |
dc.subject.other | Benzamides.therapeutic use | en |
dc.subject.other | Female | en |
dc.subject.other | Follow-Up Studies | en |
dc.subject.other | Fusion Proteins, bcr-abl.genetics.metabolism | en |
dc.subject.other | Humans | en |
dc.subject.other | Leukemia, Myelogenous, Chronic, BCR-ABL Positive.drug therapy.metabolism.mortality | en |
dc.subject.other | Male | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Piperazines.therapeutic use | en |
dc.subject.other | Prognosis | en |
dc.subject.other | Pyrimidines.therapeutic use | en |
dc.subject.other | Remission Induction | en |
dc.subject.other | Survival Rate | en |
dc.subject.other | Time Factors | en |
dc.title | Prognosis for patients with CML and >10% BCR-ABL1 after 3 months of imatinib depends on the rate of BCR-ABL1 decline. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Blood | en |
dc.identifier.affiliation | Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, Australia | en |
dc.identifier.affiliation | University of Melbourne, Parkville, Australia | en |
dc.identifier.affiliation | Department of Haematology, Austin Hospital, Melbourne, Australia | en |
dc.identifier.affiliation | Department of Haematology, Flinders University and Medical Centre, Bedford Park, Australia | en |
dc.identifier.affiliation | Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia | en |
dc.identifier.affiliation | School of Pharmacy and Medical Science, University of South Adelaide, Adelaide, Australia | en |
dc.identifier.affiliation | School of Medicine, and School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia | en |
dc.identifier.affiliation | School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia | en |
dc.identifier.affiliation | Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, Australia | en |
dc.identifier.affiliation | Australasian Leukaemia and Lymphoma Group, East Melbourne, Australia | en |
dc.identifier.affiliation | School of Medicine, and Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia | en |
dc.identifier.doi | 10.1182/blood-2014-03-566323 | en |
dc.description.pages | 511-8 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/24859364 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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