Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12034
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dc.contributor.authorSinclair, Marie-
dc.contributor.authorKet, Shara-
dc.contributor.authorTestro, Adam G-
dc.contributor.authorGow, Paul J-
dc.contributor.authorAngus, Peter W-
dc.date.accessioned2015-05-16T01:40:42Z
dc.date.available2015-05-16T01:40:42Z
dc.date.issued2014-02-01-
dc.identifier.citationObstetrics and Gynecology; 123(2 Pt 2 Suppl 2): 480-3en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12034en
dc.description.abstractAbnormal liver function tests are common in pregnancy; however, liver failure is rare. Pregnancy is a catabolic state that can precipitate illness in patients with underlying metabolic disorders.A 19-year-old woman presented at 14 weeks of gestation with an alanine transaminase of 2,252 international units/L (less than 30), an international normalized ratio of 6.9 (0.9-1.2), and an ammonia of 58 micromole/L (11-51 micromole/L). No cause was identified on routine investigations including liver biopsy. Biochemical and clinical deterioration prompted investigation for a metabolic disorder. Urinary orotic acid was elevated, consistent with the urea cycle disorder type 1 citrullinemia. Appropriate management (arginine supplementation and dietary protein restriction) led to rapid improvement and later delivery of a healthy neonate.This is an unusual presentation that reminds us of the importance of considering metabolic disorders during the catabolic stress of pregnancy.en_US
dc.language.isoenen
dc.subject.otherCitrullinemia.complications.diagnosisen
dc.subject.otherDiagnosis, Differentialen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherLiver Failure, Acute.diagnosisen
dc.subject.otherPregnancyen
dc.subject.otherPregnancy Complications.diagnosisen
dc.subject.otherYoung Adulten
dc.titleAcute hepatic decompensation precipitated by pregnancy-related catabolic stress: a rare mimic of acute liver failure.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleObstetrics and Gynecologyen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.doi10.1097/AOG.000000000000005en_US
dc.description.pages480-3en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24413235en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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