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Title: Effect of chronic enalapril treatment on enzymes responsible for the catabolism of angiotensin I and formation of angiotensin II.
Austin Authors: Drummer, Olaf H;Kourtis, S;Johnson, H
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Australia
Issue Date: 1-Feb-1990
Publication information: Biochemical Pharmacology; 39(3): 513-8
Abstract: We have investigated the effect of chronic administration of enalapril on the carboxypeptidases responsible for the formation of angiotensin II from angiotensin I and other peptidases known to recognize angiotensin I as a substrate in the rat. These studies have shown an increase in activity in rate of formation of des-Leu-angiotensin I in both kidney S2 and P2 centrifugal fractions as well as a decrease in the rate of degradation of angiotensin I substrate. Similar increases in the formation of A(1-8) have been observed in kidney using A(1-9) as substrate. These two enzyme activities have been named carboxypeptidase K1 and K2, respectively to reflect their presence in rat kidney. These changes were accompanied by significant decreases in the activity of an amastatin-sensitive aminopeptidase and endopeptidase 24.11 in the kidney P2 fraction. These data suggest that chronic treatment with ACE inhibitors may differentially affect the activity of other enzymes capable of degrading angiotensin causing a substantial re-direction of angiotensin metabolism.
Gov't Doc #: 2407244
Type: Journal Article
Subjects: Aminopeptidases.metabolism
Angiotensin I.metabolism
Angiotensin II.metabolism
Angiotensin-Converting Enzyme Inhibitors.pharmacology
Anti-Bacterial Agents
Chromatography, High Pressure Liquid
Enalapril.administration & dosage.pharmacology
Kidney.drug effects.enzymology
Peptide Fragments.isolation & purification.metabolism
Rats, Inbred WKY
Appears in Collections:Journal articles

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