Please use this identifier to cite or link to this item:
|Title:||Localization of preprogalanin mRNA in rat brain: in situ hybridization study with a synthetic oligonucleotide probe.||Austin Authors:||Gundlach, Andrew L;Wisden, W;Morris, B J;Hunt, S P||Affiliation:||University of Melbourne Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia||Issue Date:||13-Jul-1990||Publication information:||Neuroscience Letters; 114(3): 241-7||Abstract:||Galanin is a peptide containing 29 amino acid residues that is present in both the central and peripheral nervous systems. Galanin has multiple putative biological functions including regulation of hormone release, stimulation of feeding behaviour, and effects on blood pressure. This study examined the distribution of neurones expressing preprogalanin mRNA in the rat brain by in situ hybridization of a specific 35S-labelled oligonucleotide. Preprogalanin mRNA was detected in several regions of brain, with high concentrations in the paraventricular, periventricular, supraoptic, dorsomedial and arcuate nuclei of the hypothalamus; the locus coeruleus and dorsal raphe nucleus in the pons; and the nucleus tractus solitarii and ventrolateral reticular nucleus in the medulla. These findings are consistent with studies of the cellular localization of galanin-like immunoreactivity in rat brain, and further suggest the involvement of galanin in the regulation of several functions ranging from water balance to blood pressure control.||Gov't Doc #:||2402333||URI:||https://ahro.austin.org.au/austinjspui/handle/1/11868||Journal:||Neuroscience letters||URL:||https://pubmed.ncbi.nlm.nih.gov/2402333||Type:||Journal Article||Subjects:||Animals
Nucleic Acid Hybridization
|Appears in Collections:||Journal articles|
Show full item record
checked on Dec 7, 2023
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.