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dc.contributor.authorFletcher, D Ren
dc.contributor.authorBraslis, K Gen
dc.contributor.authorShulkes, Arthuren
dc.contributor.authorHardy, Kenneth Johnen
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 17(7): 467-76en
dc.description.abstract1. Calcitonin gene-related peptide (CGRP) is a product of alternate splicing of the calcitonin gene. It is found in nerves in the vasculature and is known from in vitro studies to be a potent vasodilator. It is found abnormally in the circulation of patients with medullary thyroid carcinoma (MTC) and has been proposed to be a cause of symptoms. This study was designed to determine the dose-response effects of CGRP infusion in the intact conscious sheep on blood flow to liver and kidney, organs known to be richly innervated by CGRP-containing nerves. 2. Blood flow was measured by an indicator dilution technique using [131I]-labelled iodohippurate. CGRP infusion at both 1 and 5 pmol/kg per min produced significant (P less than 0.05) increases in both renal and hepatic blood flow. This increase in flow occurred despite a significant fall in perfusion pressure (P less than 0.05) at the higher infusion rate. At the highest infusion rate of 10 pmol/kg per min, when fall in perfusion pressure was even more marked, renal and hepatic blood flow was maintained. 3. We conclude that CGRP is vasodilatory in the renal and hepatic vascular beds and propose that nerves containing CGRP in those vessels may have a role in maintaining blood flow to those organs.en
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherCalcitonin Gene-Related Peptide.blood.pharmacologyen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherIodohippuric Acid.diagnostic useen
dc.subject.otherLiver Circulation.drug effectsen
dc.subject.otherRenal Circulation.drug effectsen
dc.subject.otherVasodilator Agentsen
dc.titleCalcitonin gene related peptide: vasodilator in ovine hepatic and renal vasculature.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin Hospital, Victoria, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
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