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dc.contributor.authorEkinci, Elif Ien
dc.contributor.authorLu, Zhong Xen
dc.contributor.authorSikaris, Kenen
dc.contributor.authorBittar, Intissaren
dc.contributor.authorCheong, Karey Yen
dc.contributor.authorLam, Queen
dc.contributor.authorCrinis, Nicken
dc.contributor.authorHoulihan, Christine Aen
dc.identifier.citationAnnals of Clinical Biochemistry 2013; 50(Pt 6): 595-602en
dc.description.abstractTrimester-specific reference intervals (RIs) for thyroid function tests are lacking for Beckman Dxl 800 analysers. We aimed to establish RIs for thyroid stimulating hormone (TSH), free thyroxine (fT4) and to track intraindividual changes in thyroid function throughout pregnancy.One hundred and thirty healthy women without antithyroid peroxidase antibodies were followed longitudinally. Thyroid function was determined at trimester-1 (T1): 9-13 weeks; trimester-2 (T2): 22-26 weeks; trimester-3 (T3): 35-39 weeks and postpartum (PP): 8-12 weeks. A subgroup (n = 47) was used to track intraindividual changes using PP as non-pregnant state (baseline).For trimesters 1-3, TSH (median (2.5th, 5th, 95th and 97.5th percentile)) was 0.77 (0.03, 0.05, 2.33, 3.05), 1.17 (0.42, 0.47, 2.71, 3.36) and 1.35 (0.34, 0.42, 2.65, 2.83) mIU/L, respectively. Free T4 (mean (95%CI)) was 10.7 (5.9-15.5), 8.1 (4.9-11.3), 7.8 (4.5-11.0) pmol/L, respectively. In T2 and T3, 36% and 41% of the fT4 values, respectively, fell below the non-pregnancy lower normal limit. In the subgroup assessed for longitudinal changes, of the women with baseline TSH ≤ median, 71-75% remained at or below the corresponding median for trimesters 1-3. Of the women with baseline fT4 ≤ median, 69-81% also remained at or below the corresponding median for trimesters 1-3. High correlation was observed at different trimesters and baseline for TSH (Spearman's r: 0.593-0.846, P < 0.001) and for fT4 (r: 0.480-0.739, P < 0.001).Use of trimester-specific RIs would prevent misclassification of thyroid function during pregnancy. In the majority of women, TSH and fT4 tracked on the same side of the median distribution, from a non-pregnant baseline, throughout pregnancy.en
dc.subject.otherBeckman Dxl 800 analyseren
dc.subject.otherfree T3en
dc.subject.otherfree T4en
dc.subject.otherthyroid functionen
dc.subject.otherthyroid stimulating hormoneen
dc.subject.othertrimester-specific reference intervalsen
dc.subject.otherLongitudinal Studiesen
dc.subject.otherPregnancy Trimesters.blood.physiologyen
dc.subject.otherReference Standardsen
dc.subject.otherThyroid Function Tests.standardsen
dc.titleLongitudinal assessment of thyroid function in pregnancy.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnnals of clinical biochemistryen
dc.identifier.affiliationDepartment of Endocrinology, Austin Health, Melbourne, Australiaen
dc.type.austinJournal Articleen
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