Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11788
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dc.contributor.authorTsai, Meng-Hanen
dc.contributor.authorPardoe, Heath Ren
dc.contributor.authorPerchyonok, Yuliyaen
dc.contributor.authorFitt, Gregory Jen
dc.contributor.authorScheffer, Ingrid Een
dc.contributor.authorJackson, Graeme Den
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T01:24:58Z
dc.date.available2015-05-16T01:24:58Z
dc.date.issued2013-06-07en
dc.identifier.citationNeurology 2013; 81(2): 144-9en
dc.identifier.govdoc23749796en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11788en
dc.description.abstractWe sought evidence of a hereditary component for hippocampal sclerosis (HS) by determining whether close relatives of probands with temporal lobe epilepsy (TLE) with HS also had asymptomatic HS or subtle variation in hippocampal morphology.First-degree relatives from 15 families in which probands had TLE with HS and 32 age- and sex-matched controls were included in the study. Left and right hippocampal volumes and T2 relaxometry were measured using 3-tesla MRI.Thirty-two asymptomatic first-degree relatives and 3 relatives with a history of seizures or epilepsy were studied. None of the first-degree relatives had HS on visual analysis and T2 relaxation times were normal, excluding the presence of HS. Mean hippocampal volume was smaller (6.4%) in asymptomatic relatives (2.94 ± 0.27 cm(3), 95% confidence interval = 2.87-3.01) than in controls (3.14 ± 0.22 cm(3), 95% confidence interval = 3.09-3.19, p < 0.005); the effect was greater in relatives of probands with a positive family history of epilepsy. The relatives also had more asymmetric hippocampi (asymmetric index 0.92 ± 0.05) than controls (0.96 ± 0.03, p = 0.001).Small asymmetric hippocampi in healthy relatives are likely to represent a familial developmental variant that may predispose to the formation of TLE with HS. The underlying histopathology of these small hippocampi is unknown. This observation may provide an imaging marker for future studies seeking susceptibility genes for HS.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherElectroencephalographyen
dc.subject.otherEpilepsy, Temporal Lobe.complications.genetics.pathologyen
dc.subject.otherFemaleen
dc.subject.otherGenetic Predisposition to Diseaseen
dc.subject.otherHippocampus.pathologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imaging.instrumentation.methodsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPedigreeen
dc.subject.otherSclerosis.etiology.genetics.pathologyen
dc.subject.otherYoung Adulten
dc.titleEtiology of hippocampal sclerosis: evidence for a predisposing familial morphologic anomaly.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, Austin Health, University of Melbourne, Australiaen
dc.identifier.doi10.1212/WNL.0b013e31829a33acen
dc.description.pages144-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23749796en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRadiology-
crisitem.author.deptRadiology-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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