Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11760
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAllen, A Men
dc.contributor.authorYamada, Hen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T01:23:15Z
dc.date.available2015-05-16T01:23:15Z
dc.date.issued1990-07-01en
dc.identifier.citationInternational Journal of Cardiology; 28(1): 25-33en
dc.identifier.govdoc2365529en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11760en
dc.description.abstractThe distribution of binding to angiotensin II receptors in the rat heart was determined by quantitative in vitro autoradiography employing 125I-[Sar1, Ile8] angiotensin II as the radioligand. Low density binding occurs in the myocardium of both the atriums and ventricles and in the media of the aorta, pulmonary arteries and superior caval vein. Dense punctate binding is found over parasympathetic nerve bundles and some cells of the intracardiac ganglions. Binding is very low in nerves which do not stain for acetylcholinesterase. A moderate to high density of binding sites occurs throughout the conduction system, including the sinus node (low), the atrioventricular node (high) and the atrioventricular bundle (moderate). An extremely high density of binding is observed over the remnant of the arterial duct. These findings demonstrate many sites at which angiotensin II could exert its cardiac actions, including anatomical evidence supporting an action on cardiac myocytes, terminals of the vagal nerves, parasympathetic ganglion cells, and the conduction system.en
dc.language.isoenen
dc.subject.otherAngiotensin II.metabolismen
dc.subject.otherAnimalsen
dc.subject.otherAutonomic Nervous System.metabolismen
dc.subject.otherAutoradiographyen
dc.subject.otherBinding Sitesen
dc.subject.otherHeart.innervationen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherIodine Radioisotopesen
dc.subject.otherMaleen
dc.subject.otherMyocardium.metabolismen
dc.subject.otherRadioligand Assayen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Angiotensin.metabolismen
dc.titleIn vitro autoradiographic localization of binding to angiotensin receptors in the rat heart.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational journal of cardiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages25-33en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2365529en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

2
checked on Feb 3, 2023

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.