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Title: The role of natural killer cells in hepatitis C infection.
Austin Authors: Howell, Jessica;Visvanathan, Kumar
Affiliation: Liver Transplant Unit, Austin Hospital, Melbourne, Australia
Issue Date: 4-Apr-2013
Publication information: Antiviral Therapy 2013; 18(7): 853-65
Abstract: HCV infection is an exponentially growing health burden worldwide, with an estimated 170 million people infected. Although therapies for HCV are continually improving, there remain a considerable proportion of patients who do not achieve viral eradication and develop liver disease. Natural killer (NK) cells are crucial for T-cell activation and are one of the first-line sentinel cell responders to viral infection. A recent explosion in studies exploring the role of NK cells in HCV infection has yielded important mechanistic information and intriguing potential therapeutic options for HCV infection. This review provides a general overview of normal NK cell function and outlines some of the important mechanisms characterizing the immune interplay between NK cells and HCV infection.
Gov't Doc #: 23559549
DOI: 10.3851/IMP2565
Type: Journal Article
Subjects: Adaptive Immunity
Hepatitis C.complications.immunology.metabolism
Hepatitis C, Chronic
Immunity, Innate
Killer Cells, Natural.immunology.metabolism
Liver Cirrhosis.etiology
Lymphocyte Activation.immunology
Natural Killer T-Cells.immunology.metabolism
Receptors, Natural Killer Cell.metabolism
Receptors, Pattern Recognition.metabolism
Appears in Collections:Journal articles

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