Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11722
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dc.contributor.authorAlford, Simone Len
dc.contributor.authorPrassas, Georgina Nen
dc.contributor.authorVogelesang, Cathy Ren
dc.contributor.authorLeggett, Heather Jen
dc.contributor.authorHamilton, Christopher Sen
dc.date.accessioned2015-05-16T01:20:51Z
dc.date.available2015-05-16T01:20:51Z
dc.date.issued2013-03-26en
dc.identifier.citationJournal of Medical Imaging and Radiation Oncology 2013; 57(2): 222-9en
dc.identifier.govdoc23551785en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11722en
dc.description.abstractWe sought to assess the cosmetic outcomes and the proportion of patients with late radiotherapy toxicity in a group of women with early-stage breast cancer treated with breast-conserving surgery (BCS) and adjuvant radiotherapy using a simultaneous integrated boost (SIB) technique.Female patients with early-stage breast cancer (pT1-2 N0-1) treated with BCS and radiotherapy using an SIB technique were identified retrospectively from the departmental database. Radiotherapy consisted of 45 Gy in 25 fractions delivered to the whole breast with a simultaneous forward-planned conformal boost to the tumour bed of 60 Gy in 25 fractions. Demographic data, as well as prospectively collected measures of toxicity and cosmesis, were recorded and analysed.Fifty-five eligible patients were treated between 2009 and 2011. The median age was 61 years (range, 31 to 81 years). Median follow-up was 13.3 months. Late toxicities (including oedema, pigmentation, telangiectasia, fibrosis, osteonecrosis and pain) were graded using Common Terminology Criteria for Adverse Events v3.0 criteria. Grade 0, 1 and 2 toxicities were assigned to 52.8%, 43.4% and 3.8% of patients, respectively. There were no cases of grade 3 or greater toxicity. Ninety-eight per cent had a good or excellent cosmetic outcome based on independent assessment by both the patient and physician. One patient developed a second primary contralateral breast cancer. There were no cases of local recurrence.The use of a conformal SIB technique is proposed as a mode of delivering adjuvant radiotherapy in early-stage breast cancer. This schedule is convenient for the patient given the shortened overall treatment time. Additionally, the SIB technique seems to be well tolerated, with minimal toxicity and acceptable cosmetic outcomes. Finally, there are dosimetric benefits with respect to target coverage and reduction of dose and dose per fraction to organs at risk.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherBreast Neoplasms.diagnosis.radiotherapyen
dc.subject.otherDose Fractionationen
dc.subject.otherEstheticsen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPatient Satisfactionen
dc.subject.otherRadiation Injuries.diagnosis.etiology.prevention & controlen
dc.subject.otherRadiotherapy Dosageen
dc.subject.otherRadiotherapy, Adjuvant.adverse effects.methodsen
dc.subject.otherTreatment Outcomeen
dc.titleAdjuvant breast radiotherapy using a simultaneous integrated boost: clinical and dosimetric perspectives.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Medical Imaging and Radiation Oncologyen
dc.identifier.affiliationDepartment of Radiation Oncology, Austin Hospital, Heidelberg, Austrsalia.en
dc.identifier.doi10.1111/j.1754-9485.2012.02473.xen
dc.description.pages222-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23551785en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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