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Title: The circulatory and renal sympathoinhibitory effects of gastric leptin are altered by a high fat diet and obesity.
Austin Authors: How, Jackie M Y;Pumpa, Talia J;Sartor, Daniela M
Affiliation: University of Melbourne, Department of Medicine, Austin Health, Heidelberg, 3084, Victoria, Australia
Issue Date: 16-Mar-2013
Publication information: Autonomic Neuroscience : Basic & Clinical 2013; 177(2): 95-100
Abstract: Gastric leptin elicits its cardiovascular and splanchnic sympathoinhibitory responses via a vagal afferent mechanism, however the latter are blunted/abolished in animals fed a medium high fat diet (MHFD). In a diet-induced obesity model we sought to determine whether the renal sympathetic nerve discharge (RSND) and regional vasodilator responses to gastric leptin are also affected by diet and/or obesity. The diet induced obesity model was used in 2 separate studies. After 13 weeks on a MHFD the animals were classified as either obesity prone (OP) or obesity resistant (OR) depending on their weight gain. Control animals were fed a low fat diet for an equivalent period. Arterial pressure (AP) and heart rate (HR) were monitored in isoflurane-anaesthetised, artificially ventilated animals and RSND or regional vascular responses to leptin (15 μg/kg) administered close to the coeliac artery were evaluated. OP rats had higher baseline AP compared to control/OR rats (P<0.05). Close arterial leptin inhibited RSND in control animals but this response was abolished in OR and OP animals (P<0.01 for both). Leptin administration increased renal vascular conductance in control animals but this response was significantly attenuated only in OP animals (P<0.05). The vasodilator response in the superior mesenteric artery was not significantly different in any of the groups (P>0.05). Together these results suggest that, while the renal sympathoinhibitory responses to gastric leptin are affected by diet, the vasodilator responses to leptin in the renal vascular bed are only affected in OP animals. These changes may impact on cardiovascular homeostatic mechanisms in obesity.
Gov't Doc #: 23506793
DOI: 10.1016/j.autneu.2013.02.018
Type: Journal Article
Subjects: Leptin
Sympathetic nerve
Blood Pressure.drug effects.physiology
Celiac Artery.drug effects.metabolism
Diet, Fat-Restricted.methods
Diet, High-Fat.methods
Heart Rate.drug effects.physiology
Kidney.blood supply.drug effects.innervation
Leptin.administration & dosage.blood
Neural Inhibition.drug effects.physiology
Obesity.blood.prevention & control
Rats, Sprague-Dawley
Sympathetic Fibers, Postganglionic.drug effects.metabolism
Treatment Outcome
Vasodilation.drug effects.physiology
Appears in Collections:Journal articles

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