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Title: Toll-like receptors in hepatitis C infection: implications for pathogenesis and treatment.
Austin Authors: Howell, Jessica;Angus, Peter W ;Gow, Paul J ;Visvanathan, Kumar
Affiliation: Victorian Liver Transplant Unit
Issue Date: 1-May-2013
Publication information: Journal of Gastroenterology and Hepatology; 28(5): 766-76
Abstract: Hepatitis C virus (HCV) infection is a significant global health problem, affecting over 150 million people worldwide. While the critical role of the adaptive immune system in HCV infection is well-established, the importance of the innate immune system in HCV infection has only been recognized in more recent years. Toll-like receptors form the cornerstone of the innate immune response, and there is considerable evidence for their crucial role in hepatitis C infection. This review outlines recent advances made in our understanding of the role of Toll-like receptor function in HCV infection, exploring how HCV manipulates host immunity to evade immune clearance and establish persistent infection despite leading to inflammatory hepatic damage.
DOI: 10.1111/jgh.12170
Journal: Journal of Gastroenterology and Hepatology
Type: Journal Article
Subjects: Adaptive Immunity.immunology
Dendritic Cells.immunology
Hepatitis C.immunology.therapy
Immunity, Innate.immunology
Inflammation Mediators.metabolism
Molecular Targeted Therapy
Signal Transduction.immunology
Toll-Like Receptors.chemistry.immunology.physiology
Appears in Collections:Journal articles

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