Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11580
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dc.contributor.authorSohawon, Dharamrajen
dc.contributor.authorLau, Kenneth Ken
dc.contributor.authorLau, Theodoreen
dc.contributor.authorBowden, Donald Ken
dc.date.accessioned2015-05-16T01:11:42Z
dc.date.available2015-05-16T01:11:42Z
dc.date.issued2012-06-25en
dc.identifier.citationJournal of Medical Imaging and Radiation Oncology 2012; 56(5): 538-44en
dc.identifier.govdoc23043573en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11580en
dc.description.abstractExtra-medullary haematopoiesis (EMH) occurs in many haematological disorders and is secondary to insufficient bone marrow function or ineffective erythropoiesis. It usually presents as haematopoietic masses in several typical and atypical body locations. This pictorial review briefly discusses the common EMH locations encountered in clinical practice, including the liver, spleen, lymph nodes and paravertebral regions. Unusual presentation as focal hepatic and splenic masses is also discussed. Some atypical EMH locations are then presented together with their pathophysiology and relevant illustrations. These include EMH in the intra-spinal canal, pre-sacral region, nasopharynx and paranasal sinuses. Intra-spinal EMH can cause cord compression and present with neurological symptoms. In these cases, urgent treatment may be required. Haematopoietic masses in the other atypical locations can present with obstructive symptoms or may be diagnosed incidentally on imaging. EMH in unusual locations need to be monitored with follow-up imaging to ensure their stability. In some circumstances, tissue biopsy is appropriate to confirm the diagnosis and exclude other sinister pathology (e.g. malignancy). Treatment is only required where symptoms are present. Management options include blood transfusion, radiotherapy, hydroxyurea or surgical resection in selected cases.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherFemaleen
dc.subject.otherHematologic Diseases.pathologyen
dc.subject.otherHematopoiesis, Extramedullaryen
dc.subject.otherHumansen
dc.subject.otherImage Enhancement.methodsen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherTomography, X-Ray Computed.methodsen
dc.subject.otherYoung Adulten
dc.titleExtra-medullary haematopoiesis: a pictorial review of its typical and atypical locations.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Medical Imaging and Radiation Oncologyen
dc.identifier.affiliationDepartment of Surgery, Austin Health, Nursing and Health Sciences Centre for Green Chemistry, Monash University, Queensland, Australiaen
dc.identifier.doi10.1111/j.1754-9485.2012.02397.xen
dc.description.pages538-44en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23043573en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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