Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11425
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dc.contributor.authorWookey, Peter Jen
dc.contributor.authorTurner, Kirstyen
dc.contributor.authorFurness, John Ben
dc.date.accessioned2015-05-16T01:01:55Z
dc.date.available2015-05-16T01:01:55Z
dc.date.issued2012-01-22en
dc.identifier.citationCell and Tissue Research 2012; 347(2): 311-7en
dc.identifier.govdoc22271140en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11425en
dc.description.abstractCalcitonin receptor-immunoreactivity (CTR-ir) was found in enteric neurons of the mouse gastrointestinal tract from embryonic day 13.5 (E13.5) to post-natal day 28 (P28). CTR-ir occurred in cell bodies in ganglia of the myenteric plexus extending from the esophagus to the colon and in nerve cells of the submucosal ganglia of the small and large intestines. CTR-ir was also found in vagal nerve trunks and mesenteric nerves. Counts in the ileal myenteric plexus revealed CTR-ir in 80% of neurons. CTR-ir was clearly evident in the cell bodies of enteric neurons by E15.5. The immunoreactivity reached maximum intensity between P1.5 and P12 but was weaker at P18 and barely detectable at P28. The receptor was detected in nerve processes in the intestine for only a brief period around E17.5, when it was present in one to two axonal processes per villus in the small intestine. In late gestation and soon after birth, CTR-ir was also evident in the mucosal epithelium. The perinatal expression of CTR within the ENS suggests that the calcitonin/CTR system may have a role in the maturation of enteric neurons. Signals may reach enteric neurons in milk, which contains high levels of calcitonin.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherEmbryo, Nonmammalian.metabolismen
dc.subject.otherEnteric Nervous System.metabolismen
dc.subject.otherIleum.metabolismen
dc.subject.otherIntestine, Small.metabolismen
dc.subject.otherMiceen
dc.subject.otherNeurons.metabolismen
dc.subject.otherReceptors, Calcitonin.metabolismen
dc.subject.otherSubmucous Plexus.metabolismen
dc.subject.otherVagus Nerve.metabolismen
dc.titleTransient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse.en
dc.typeJournal Articleen
dc.identifier.journaltitleCell and tissue researchen
dc.identifier.affiliationDepartment of Medicine at Austin Health, University of Melbourne, Parkville, VIC 3010, Australiaen
dc.identifier.doi10.1007/s00441-011-1303-6en
dc.description.pages311-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22271140en
dc.type.austinJournal Articleen
local.name.researcherWookey, Peter J
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptMedicine (University of Melbourne)-
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