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Title: Temperature dependence of angiotensin II-mediated depolarisation of the rat isolated nodose ganglion.
Austin Authors: Widdop, Robert E;Krstew, E;Jarrott, B
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 21-Aug-1990
Publication information: European Journal of Pharmacology; 185(1): 107-11
Abstract: The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room temperature (20-24 degrees C) and at 35-37 degrees C. However, A II depolarised the nodose ganglion only under the latter condition, and these responses were blocked by the A II receptor antagonist saralasin. This study extends previous findings which have demonstrated A II binding sites on the nodose ganglion and axon, and identifies the rat nodose ganglion as a sensitive preparation in which to study the interactions between neuronal A II receptor activation and its blockade by A II receptor antagonists.
Gov't Doc #: 2226630
Journal: European Journal of Pharmacology
Type: Journal Article
Subjects: Angiotensin II.physiology
Dose-Response Relationship, Drug
Neuromuscular Depolarizing Agents
Nodose Ganglion.drug effects.physiology
Rats, Inbred Strains
Appears in Collections:Journal articles

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