Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11285
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFabris, Bruno-
dc.contributor.authorYamada, H-
dc.contributor.authorCubela, R B-
dc.contributor.authorJackson, B-
dc.contributor.authorMendelsohn, Frederick AO-
dc.contributor.authorJohnston, Colin I-
dc.date.accessioned2015-05-16T00:52:28Z
dc.date.available2015-05-16T00:52:28Z
dc.date.issued1990-07-01-
dc.identifier.citationBritish Journal of Pharmacology; 100(3): 651-5en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11285en
dc.description.abstract1. Angiotensin converting enzyme (ACE) from the rat heart and lung was studied by use of the radioligand [125I]-351A. 2. Displacement of the bound radioinhibitor [125I]-351A was used to assess the relative potency of six ACE inhibitors in rat heart and lung homogenates and estimate the binding association constant (KA). 3. The KA for atrial preparations was significantly higher than that of the lung (P less than 0.025) and also the ventricles (P less than 0.005). Ventricular preparations and preparations from the lung also differed significantly (P less than 0.05). These differences in KA were noted for all six ACE inhibitors used to displace the radioligand. 4. The rank order of potency of the ACE inhibitors was quinaprilat = benazeprilat greater than perindoprilat greater than 351A greater than lisinopril greater than fosinoprilat. 5. Cardiac ACE inhibition was studied ex vivo following oral administration of quinapril to rats. Following 0.3 mg kg-1 quinapril, the time course and degree of inhibition of ventricular and atrial ACE were similar. 6. These results suggest that the detected differences in KA noted have only a limited potential biological significance. The difference in KA may reflect variations in the structure or conformation of ACE in different tissues.en_US
dc.language.isoenen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.diagnostic use.metabolismen
dc.subject.otherAnimalsen
dc.subject.otherDipeptides.diagnostic useen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherIsoquinolines.blood.diagnostic useen
dc.subject.otherKineticsen
dc.subject.otherLung.enzymologyen
dc.subject.otherMaleen
dc.subject.otherMyocardium.enzymologyen
dc.subject.otherPeptidyl-Dipeptidase A.analysisen
dc.subject.otherRadioligand Assayen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherTetrahydroisoquinolinesen
dc.titleCharacterization of cardiac angiotensin converting enzyme (ACE) and in vivo inhibition following oral quinapril to rats.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBritish Journal of Pharmacologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages651-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2167741en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherJackson, Belinda D
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptGastroenterology and Hepatology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

8
checked on Mar 27, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.