Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/11259
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gu, X H | en |
dc.contributor.author | Casley, David J | en |
dc.contributor.author | Cincotta, M | en |
dc.contributor.author | Nayler, W G | en |
dc.date.accessioned | 2015-05-16T00:50:53Z | |
dc.date.available | 2015-05-16T00:50:53Z | |
dc.date.issued | 1990-02-27 | en |
dc.identifier.citation | European Journal of Pharmacology; 177(3): 205-9 | en |
dc.identifier.govdoc | 2155810 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/11259 | en |
dc.description.abstract | 125I-labelled endothelin-1 was used to identify specific high affinity endothelin-1 binding sites in left ventricular and brain membranes harvested from female age-matched normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Relative to results obtained for brain membranes from normotensive rats, brain membranes from hypertensive rats exhibited an increase in 125I-endothelin-1 binding site density (P less than 0.02). In left ventricular membranes from the hypertensive rats 125I-endothelin-1 binding site density was reduced (P less than 0.02), relative to the density in ventricular membranes of normotensive rats. These results indicate that hypertension may have an organ specific effect on 125I-endothelin-1 binding site density. | en |
dc.language.iso | en | en |
dc.subject.other | Animals | en |
dc.subject.other | Blood Pressure | en |
dc.subject.other | Brain.metabolism | en |
dc.subject.other | Endothelins | en |
dc.subject.other | Female | en |
dc.subject.other | Heart Rate | en |
dc.subject.other | Hypertension.metabolism | en |
dc.subject.other | Iodine Radioisotopes.diagnostic use | en |
dc.subject.other | Kinetics | en |
dc.subject.other | Membranes.metabolism | en |
dc.subject.other | Myocardial Contraction | en |
dc.subject.other | Myocardium.metabolism | en |
dc.subject.other | Organ Size | en |
dc.subject.other | Peptides.metabolism | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Inbred SHR | en |
dc.subject.other | Rats, Inbred WKY | en |
dc.subject.other | Receptors, Cell Surface.metabolism | en |
dc.subject.other | Receptors, Endothelin | en |
dc.title | 125I-endothelin-1 binding to brain and cardiac membranes from normotensive and spontaneously hypertensive rats. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | European Journal of Pharmacology | en |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 205-9 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/2155810 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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