Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11259
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dc.contributor.authorGu, X Hen
dc.contributor.authorCasley, David Jen
dc.contributor.authorCincotta, Men
dc.contributor.authorNayler, W Gen
dc.date.accessioned2015-05-16T00:50:53Z
dc.date.available2015-05-16T00:50:53Z
dc.date.issued1990-02-27en
dc.identifier.citationEuropean Journal of Pharmacology; 177(3): 205-9en
dc.identifier.govdoc2155810en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11259en
dc.description.abstract125I-labelled endothelin-1 was used to identify specific high affinity endothelin-1 binding sites in left ventricular and brain membranes harvested from female age-matched normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Relative to results obtained for brain membranes from normotensive rats, brain membranes from hypertensive rats exhibited an increase in 125I-endothelin-1 binding site density (P less than 0.02). In left ventricular membranes from the hypertensive rats 125I-endothelin-1 binding site density was reduced (P less than 0.02), relative to the density in ventricular membranes of normotensive rats. These results indicate that hypertension may have an organ specific effect on 125I-endothelin-1 binding site density.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressureen
dc.subject.otherBrain.metabolismen
dc.subject.otherEndothelinsen
dc.subject.otherFemaleen
dc.subject.otherHeart Rateen
dc.subject.otherHypertension.metabolismen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherKineticsen
dc.subject.otherMembranes.metabolismen
dc.subject.otherMyocardial Contractionen
dc.subject.otherMyocardium.metabolismen
dc.subject.otherOrgan Sizeen
dc.subject.otherPeptides.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherReceptors, Cell Surface.metabolismen
dc.subject.otherReceptors, Endothelinen
dc.title125I-endothelin-1 binding to brain and cardiac membranes from normotensive and spontaneously hypertensive rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Pharmacologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages205-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2155810en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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