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Title: Culture of human smooth muscle cells.
Austin Authors: Gallicchio, M A
Affiliation: Department of Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 2001
Publication information: Methods in Molecular Medicine; 52(): 137-46
Abstract: The wall of a human artery consists of three distinct tunics. The tunica intima is lined by a layer of endothelial cells facing the lumen. Smooth muscle cells (SMCs) are the predominant cell type in the tunica media of arteries. They are surrounded by a basal lamina containing collagen IV, proteoglycans, glycosaminoglycans, glycoproteins, and extracellular matrix (ECM) molecules: collagens type 1, III, V, and VI, and elastin. The external tunica adventitia consists primarily of collagen fibers, elastic tissue, and fibroblasts. Because smooth muscle cells play a dominant role in the development of intimal hyperplasia during atherosclerosis, these cells have been studied extensively in vitro.
Gov't Doc #: 21340937
DOI: 10.1385/1-59259-073-X:137
Journal: Methods in molecular medicine
Type: Journal Article
Appears in Collections:Journal articles

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