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|Title:||Culture of human smooth muscle cells.||Austin Authors:||Gallicchio, M A||Affiliation:||Department of Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Victoria, Australia||Issue Date:||2001||Publication information:||Methods in Molecular Medicine; 52(): 137-46||Abstract:||The wall of a human artery consists of three distinct tunics. The tunica intima is lined by a layer of endothelial cells facing the lumen. Smooth muscle cells (SMCs) are the predominant cell type in the tunica media of arteries. They are surrounded by a basal lamina containing collagen IV, proteoglycans, glycosaminoglycans, glycoproteins, and extracellular matrix (ECM) molecules: collagens type 1, III, V, and VI, and elastin. The external tunica adventitia consists primarily of collagen fibers, elastic tissue, and fibroblasts. Because smooth muscle cells play a dominant role in the development of intimal hyperplasia during atherosclerosis, these cells have been studied extensively in vitro.||Gov't Doc #:||21340937||URI:||http://ahro.austin.org.au/austinjspui/handle/1/11212||DOI:||10.1385/1-59259-073-X:137||Journal:||Methods in molecular medicine||URL:||https://pubmed.ncbi.nlm.nih.gov/21340937||Type:||Journal Article|
|Appears in Collections:||Journal articles|
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