Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11210
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dc.contributor.authorKovac, Suzanaen
dc.contributor.authorAnderson, Gregory Jen
dc.contributor.authorBaldwin, Graham Sen
dc.date.accessioned2015-05-16T00:47:55Z
dc.date.available2015-05-16T00:47:55Z
dc.date.issued2011-02-12en
dc.identifier.citationBiochimica Et Biophysica Acta 2011; 1813(5): 889-95en
dc.identifier.govdoc21320535en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11210en
dc.description.abstractThe peptide hormone gastrin has been identified as a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. The importance of gastric acid in the absorption of dietary iron first became evident 50 years ago when iron deficiency anemia was recognized as a long-term consequence of partial gastrectomy. This review summarizes the connections between circulating gastrins, iron status and colorectal cancer. Gastrins bind two ferric ions with micromolar affinity and, in the case of non-amidated forms of the hormone, iron binding is essential for biological activity in vitro and in vivo. The demonstration of an interaction between gastrin and transferrin by biochemical techniques led to the proposal that gastrins catalyze the loading of transferrin with iron. Several lines of evidence, including the facts that the concentrations of circulating gastrins are increased in mice and humans with the iron overload disease hemochromatosis and that transferrin saturation positively correlates with circulating gastrin concentration, suggest the potential involvement of gastrins in iron homeostasis. Conversely, recognition that ferric ions play an unexpected role in the biological activity of gastrins may assist in the development of useful therapies for colorectal carcinoma and other disorders of mucosal proliferation in the gastrointestinal tract. This article is part of a Special Issue entitled: 11th European Symposium on Calcium.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBiological Transporten
dc.subject.otherColorectal Neoplasms.metabolismen
dc.subject.otherGastrins.metabolismen
dc.subject.otherHomeostasisen
dc.subject.otherHumansen
dc.subject.otherIron.metabolismen
dc.subject.otherReceptor, Cholecystokinin B.metabolismen
dc.titleGastrins, iron homeostasis and colorectal cancer.en
dc.typeJournal Articleen
dc.identifier.journaltitleBiochimica et biophysica actaen
dc.identifier.affiliationThe University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.bbamcr.2011.02.007en
dc.description.pages889-95en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/21320535en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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