Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11204
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dc.contributor.authorBaldwin, Graham Sen
dc.date.accessioned2015-05-16T00:47:33Z-
dc.date.available2015-05-16T00:47:33Z-
dc.date.issued2009-07-28en
dc.identifier.citationMetallomics : Integrated Biometal Science 2009; 1(5): 370-4en
dc.identifier.govdoc21305139en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11204en
dc.description.abstractThis minireview explores the connections between circulating gastrins, iron status and colorectal cancer. The peptide hormone gastrin is a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. Gastrins bind two ferric ions with μM affinity and, in the case of non-amidated forms of the hormone, iron binding is essential for biological activity. The ferric ion ligands have been identified as glutamates 7, 8 and 9 in the 18 amino acid peptide glycine-extended gastrin. An interaction between gastrin and transferrin was first demonstrated by covalent crosslinking techniques, and has been recently confirmed by surface plasmon resonance. We have therefore proposed that gastrins act as catalysts in the loading of transferrin with iron. Several recent lines of evidence, including the facts that the concentrations of circulating gastrins are increased in mice and humans with the iron overload disease haemochromatosis, and that transferrin saturation positively correlates with circulating gastrin concentrations, suggest that gastrins may be involved in iron homeostasis. In addition the recognition that ferric ions may play an unexpected role in the biological activity of non-amidated gastrins may assist in the development of new therapies for colorectal carcinoma.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherColorectal Neoplasms.metabolismen
dc.subject.otherGastrins.metabolismen
dc.subject.otherHumansen
dc.subject.otherIron.metabolismen
dc.subject.otherReceptor, Cholecystokinin B.metabolismen
dc.subject.otherTransferrin.metabolismen
dc.titleGastrins, iron and colorectal cancer.en
dc.typeJournal Articleen
dc.identifier.journaltitleMetallomics : integrated biometal scienceen
dc.identifier.affiliationThe University of Melbourne Department of Surgery, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1039/b909112men
dc.description.pages370-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/21305139en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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