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dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorPike, Kerryn E-
dc.contributor.authorChételat, Gaël-
dc.contributor.authorEllis, Kathryn A-
dc.contributor.authorMulligan, Rachel S-
dc.contributor.authorBourgeat, Pierrick-
dc.contributor.authorAckermann, Uwe-
dc.contributor.authorJones, Gareth-
dc.contributor.authorSzoeke, Cassandra-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorO'Keefe, Graeme J-
dc.contributor.authorMathis, Chester A-
dc.contributor.authorKlunk, William E-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.identifier.citationAnnals of Neurology; 69(1): 181-92en
dc.description.abstractAssess Aβ deposition longitudinally and explore its relationship with cognition and disease progression.Clinical follow-up was obtained 20 ± 3 months after [¹¹C]Pittsburgh compound B (PiB)-positron emission tomography in 206 subjects: 35 with dementia of the Alzheimer type (DAT), 65 with mild cognitive impairment (MCI), and 106 age-matched healthy controls (HCs). A second PiB scan was obtained at follow-up in 185 subjects and a third scan after 3 years in 57.At baseline, 97% of DAT, 69% of MCI, and 31% of HC subjects showed high PiB retention. At 20-month follow-up, small but significant increases in PiB standardized uptake value ratios were observed in the DAT and MCI groups, and in HCs with high PiB retention at baseline (5.7%, 2.1%, and 1.5%, respectively). Increases were associated with the number of apolipoprotein E ε4 alleles. There was a weak correlation between PiB increases and decline in cognition when all groups were combined. Progression to DAT occurred in 67% of MCI with high PiB versus 5% of those with low PiB, but 20% of the low PiB MCI subjects progressed to other dementias. Of the high PiB HCs, 16% developed MCI or DAT by 20 months and 25% by 3 years. One low PiB HC developed MCI.Aβ deposition increases slowly from cognitive normality to moderate severity DAT. Extensive Aβ deposition precedes cognitive impairment, and is associated with ApoE genotype and a higher risk of cognitive decline in HCs and progression from MCI to DAT over 1 to 2 years. However, cognitive decline is only weakly related to change in Aβ burden, suggesting that downstream factors have a more direct effect on symptom progression.en
dc.subject.otherAlzheimer Disease.diagnosis.pathology.radionuclide imagingen
dc.subject.otherAmyloid beta-Peptidesen
dc.subject.otherAniline Compounds.diagnostic useen
dc.subject.otherBrain.pathology.radionuclide imagingen
dc.subject.otherCognition Disorders.diagnosisen
dc.subject.otherDisease Progressionen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherLongitudinal Studiesen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherNeuropsychological Testsen
dc.subject.otherPlaque, Amyloid.diagnosis.pathology.radionuclide imagingen
dc.subject.otherPolymorphism, Geneticen
dc.subject.otherPositron-Emission Tomographyen
dc.subject.otherSeverity of Illness Indexen
dc.subject.otherThiazoles.diagnostic useen
dc.titleLongitudinal assessment of Aβ and cognition in aging and Alzheimer disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnnals of Neurologyen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Articleen, Uwe
item.openairetypeJournal Article-
item.fulltextNo Fulltext- Imaging and Therapy- Imaging and Therapy- Imaging and Therapy- Florey Institute of Neuroscience and Mental Health- Imaging and Therapy-
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