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Title: Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor.
Austin Authors: Kovac, Suzana;Xiao, Lin;Shulkes, Arthur;Patel, Oneel;Baldwin, Graham S
Affiliation: The University of Melbourne, Department of Surgery, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 8-Oct-2010
Publication information: Febs Letters 2010; 584(21): 4413-8
Abstract: The involvement of the gastrointestinal hormone gastrin in the development of gastrointestinal cancer is highly controversial. Here we demonstrate a positive-feedback loop whereby gastrin, acting via the CCK2 receptor, increases its own expression. Such an autocrine loop has not previously been reported for any other gastrointestinal hormone. Gastrin promoter activation was dependent on the MAP kinase pathway and did not involve Sp1 binding sites or epidermal growth factor receptor transactivation. As the treatment of gastrointestinal cancer cells with amidated gastrin led to increased expression of non-amidated gastrins, the positive-feedback loop may contribute to the sustained increase in circulating gastrins observed in colorectal cancer patients.
Gov't Doc #: 20932834
DOI: 10.1016/j.febslet.2010.09.046
Journal: FEBS letters
Type: Journal Article
Subjects: Base Sequence
Cell Line, Tumor
Colorectal Neoplasms.blood.genetics.metabolism
Feedback, Physiological
Gastrointestinal Neoplasms.genetics.metabolism.pathology
Gene Expression Regulation, Neoplastic
Genes, Reporter.genetics
MAP Kinase Signaling System
Molecular Sequence Data
Polymerase Chain Reaction
Promoter Regions, Genetic.genetics
Receptor, Cholecystokinin B.metabolism
Time Factors
Transcription, Genetic
Transcriptional Activation
Appears in Collections:Journal articles

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