Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11061
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dc.contributor.authorCarlberg, Men
dc.contributor.authorJarrott, Ben
dc.contributor.authorBeart, P Men
dc.date.accessioned2015-05-16T00:38:23Z
dc.date.available2015-05-16T00:38:23Z
dc.date.issued1991-01-14en
dc.identifier.citationNeuroscience Letters; 122(1): 29-32en
dc.identifier.govdoc2057133en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11061en
dc.description.abstractThe 125I-labeled sulfonated cholecystokinin (CCK) analogue, D-Tyr25(Nle28,31)-CCK(25-33), bound saturably and reversibly to membranes of rat cerebral cortex. The dissociation constant Kd was estimated to be 0.14 nM by Scatchard analysis and 0.40 nM from analyses of dissociation/association rates. Hill coefficients of 0.99, Scatchard plots and drug competition studies were consistent with a single population of binding sites. Dependence on divalent cations and inhibition by guanylyl-imidodiphosphate suggested binding to a receptor coupled to a G protein. Competition studies with CCK-analogues and non-peptide specific antagonists indicated binding to receptor sites of the B-subtype (CCKB).en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBenzodiazepinones.metabolismen
dc.subject.otherBinding, Competitiveen
dc.subject.otherCerebral Cortex.metabolismen
dc.subject.otherCholecystokinin.analogs & derivatives.metabolismen
dc.subject.otherHalf-Lifeen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherKineticsen
dc.subject.otherMaleen
dc.subject.otherMembranes.metabolismen
dc.subject.otherPeptide Fragments.metabolismen
dc.subject.otherPhenylurea Compoundsen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Cholecystokinin.antagonists & inhibitors.metabolismen
dc.titleSpecific binding of D-Tyr25 (Nle28,31)-CCK(25-33) to cortical membranes from rat brain.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroscience lettersen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Vic.en
dc.description.pages29-32en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2057133en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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