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dc.contributor.authorCulvenor, A Jen
dc.contributor.authorJarrott, Ben
dc.identifier.citationNeurochemistry International; 3(6): 365-9en
dc.description.abstractSmall intracerebral blood vessels (microvessels) of bovine brain are known to contain the vasoactive amine histamine, and the presence of histamine-H(1) receptors in microvessels was examined using the radioligand, [(3)H]mepyramine. Microvessels were isolated from cerebral cortex grey matter, striatum and hippocampus by a sieving technique and membranes prepared for binding studies. [(3)H]Mepyramine bound to a single, high affinity site, which displayed stereoselectivity for (+) chlorpheniramine relative to its (?) isomer and was consistent with binding to H(1)-receptors. The density of binding sites (B(max)), in microvessel membranes from cortical grey matter, was approximately one-third of that seen in membranes prepared from cortical grey matter. Microvessels isolated from striata and hippocampi had a similar density of H(1)-receptor sites to that seen in cortical microvessels. These results demonstrate that bovine intracerebral microvessels contain significant numbers of histamine-H(1) receptors and strengthen the hypothesis that histamine could regulate the calibre of intracerebral blood vessels.en
dc.titleComparison of histamine-H(1) receptors in bovine intracerebral microvessels with cerebral grey matter by [(3)H]mepyramine binding.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurochemistry internationalen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Hospital, Heidelberg 3084, Victoria, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
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