Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11019
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dc.contributor.authorCalamante, Fernandoen
dc.contributor.authorChristensen, Sorenen
dc.contributor.authorDesmond, Patricia Men
dc.contributor.authorOstergaard, Leifen
dc.contributor.authorDavis, Stephen Men
dc.contributor.authorConnelly, Alanen
dc.date.accessioned2015-05-16T00:35:53Z
dc.date.available2015-05-16T00:35:53Z
dc.date.issued2010-04-22en
dc.identifier.citationStroke; A Journal of Cerebral Circulation 2010; 41(6): 1169-74en
dc.identifier.govdoc20413735en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11019en
dc.description.abstractMany perfusion-related MRI parameters are used to investigate the penumbra in stroke. Although time-to-maximum (Tmax) of the residue function has been suggested as a very promising parameter, its physiological meaning and sensitivity to experimental conditions are not well-understood.We used simulations to further our understanding of the practical meaning of Tmax and to provide recommendations for its use in clinical investigations. We interpret in vivo examples guided by the simulation findings.Whereas Tmax has several attractive properties for clinical use, it is shown that its physiological interpretation is complex and affected by experimental conditions. Tmax is found to reflect a combination of delay, dispersion, and, to a lesser degree, mean transit time. It should therefore mainly be considered a measure of macrovascular characteristics. Furthermore, based on the simulations, use of temporal-interpolation is highly recommended, as is correction for slice-acquisition timing differences.Special care should be taken when setting-up Tmax thresholds for data acquired with different protocols (eg, multicenter studies) because various factors can influence the measured Tmax. Because of its complementary information, used in conjunction with delay-insensitive cerebral blood-flow, cerebral blood volume, and mean transit time maps, Tmax should provide important additional information on brain hemodynamic status.en
dc.language.isoenen
dc.subject.otherBlood Volume.physiologyen
dc.subject.otherBrain.blood supply.physiologyen
dc.subject.otherCerebrovascular Circulation.physiologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Angiography.methodsen
dc.subject.otherModels, Cardiovascularen
dc.titleThe physiological significance of the time-to-maximum (Tmax) parameter in perfusion MRI.en
dc.typeJournal Articleen
dc.identifier.journaltitleStrokeen
dc.identifier.affiliationBrain Research Institute, Neurosciences Building, Austin Health, Banksia Street, Heidelberg West, Victoria 3081, Australiaen
dc.identifier.doi10.1161/STROKEAHA.110.580670en
dc.description.pages1169-74en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20413735en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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