Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10982
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dc.contributor.authorConnellan, J Men
dc.contributor.authorDeacon, Sen
dc.contributor.authorThurlow, P Jen
dc.date.accessioned2015-05-16T00:33:39Z
dc.date.available2015-05-16T00:33:39Z
dc.date.issued1991-03-01en
dc.identifier.citationThrombosis Research; 61(5-6): 501-14en
dc.identifier.govdoc2028452en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10982en
dc.description.abstractQuinine, a drug known to induce immune mediated thrombocytopenia, has been postulated to mediate binding of drug dependent antibodies to a range of platelet membrane glycoproteins. Quinine may not act solely as a hapten however, as we have shown that it inhibits platelet aggregation (ex vivo and in vitro) and release and modifies the ability of activated platelets to bind the adhesive proteins fibrinogen and fibronectin in a dose dependent fashion. Studies on the effect of quinine on the binding of monoclonal antibodies HuPlml (GpIIIa) FMC25 (GpIX) and AN51 (GpIb) to platelets shows a selective reduction in AN51 binding. In addition quinine induced platelet antibodies from thrombocytopenic patients, in the presence of quinine, have been shown to inhibit binding of these monoclonal antibodies to platelets to varying degrees. These observations suggest that quinine causes widespread but specific conformational changes in platelet membrane antigens which may expose neoantigens resulting in the production of quinine induced antibodies.en
dc.language.isoenen
dc.subject.otherAntibodies, Monoclonal.isolation & purification.metabolismen
dc.subject.otherBlood Platelets.drug effectsen
dc.subject.otherFibrinogen.metabolismen
dc.subject.otherFibronectins.metabolismen
dc.subject.otherHumansen
dc.subject.otherImmunoglobulin G.isolation & purification.metabolismen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherPlatelet Activation.drug effectsen
dc.subject.otherPlatelet Aggregation.drug effectsen
dc.subject.otherPlatelet Aggregation Inhibitors.pharmacologyen
dc.subject.otherPlatelet Membrane Glycoproteins.drug effects.metabolismen
dc.subject.otherProtein Binding.drug effectsen
dc.subject.otherQuinine.pharmacologyen
dc.subject.otherThrombocytopenia.blood.chemically induced.immunologyen
dc.titleChanges in platelet function and reactivity induced by quinine in relation to quinine (drug) induced immune thrombocytopenia.en
dc.typeJournal Articleen
dc.identifier.journaltitleThrombosis researchen
dc.identifier.affiliationDepartment of Haematology, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages501-14en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2028452en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
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