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Title: Changes in platelet function and reactivity induced by quinine in relation to quinine (drug) induced immune thrombocytopenia.
Austin Authors: Connellan, J M;Deacon, S;Thurlow, P J
Affiliation: Department of Haematology, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Mar-1991
Publication information: Thrombosis Research; 61(5-6): 501-14
Abstract: Quinine, a drug known to induce immune mediated thrombocytopenia, has been postulated to mediate binding of drug dependent antibodies to a range of platelet membrane glycoproteins. Quinine may not act solely as a hapten however, as we have shown that it inhibits platelet aggregation (ex vivo and in vitro) and release and modifies the ability of activated platelets to bind the adhesive proteins fibrinogen and fibronectin in a dose dependent fashion. Studies on the effect of quinine on the binding of monoclonal antibodies HuPlml (GpIIIa) FMC25 (GpIX) and AN51 (GpIb) to platelets shows a selective reduction in AN51 binding. In addition quinine induced platelet antibodies from thrombocytopenic patients, in the presence of quinine, have been shown to inhibit binding of these monoclonal antibodies to platelets to varying degrees. These observations suggest that quinine causes widespread but specific conformational changes in platelet membrane antigens which may expose neoantigens resulting in the production of quinine induced antibodies.
Gov't Doc #: 2028452
Journal: Thrombosis research
Type: Journal Article
Subjects: Antibodies, Monoclonal.isolation & purification.metabolism
Blood Platelets.drug effects
Immunoglobulin G.isolation & purification.metabolism
In Vitro Techniques
Platelet Activation.drug effects
Platelet Aggregation.drug effects
Platelet Aggregation Inhibitors.pharmacology
Platelet Membrane Glycoproteins.drug effects.metabolism
Protein Binding.drug effects
Thrombocytopenia.blood.chemically induced.immunology
Appears in Collections:Journal articles

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