Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10949
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dc.contributor.authorRewell, Sarah S Jen
dc.contributor.authorFernandez, John Aen
dc.contributor.authorCox, Susan Fen
dc.contributor.authorSpratt, Neil Jen
dc.contributor.authorHogan, Lisaen
dc.contributor.authorAleksoska, Elenaen
dc.contributor.authorvan Raay, Leenaen
dc.contributor.authorLiberatore, Gabriel Ten
dc.contributor.authorBatchelor, Peter Egertonen
dc.contributor.authorHowells, David Williamen
dc.date.accessioned2015-05-16T00:31:37Z
dc.date.available2015-05-16T00:31:37Z
dc.date.issued2010-01-13en
dc.identifier.citationJournal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2010; 30(4): 729-33en
dc.identifier.govdoc20068574en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10949en
dc.description.abstractAnimal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2 h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherComorbidityen
dc.subject.otherDiabetes Mellitus, Experimental.epidemiology.physiopathologyen
dc.subject.otherDisease Models, Animalen
dc.subject.otherHumansen
dc.subject.otherHypertension.epidemiology.physiopathologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherStroke.epidemiology.mortality.physiopathologyen
dc.titleInducing stroke in aged, hypertensive, diabetic rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolismen
dc.identifier.affiliationNational Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1038/jcbfm.2009.273en
dc.description.pages729-33en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20068574en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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