Inducing stroke in aged, hypertensive, diabetic rats.

2010-01-13

Rewell, Sarah S J

Fernandez, John A

Cox, Susan F

Spratt, Neil J

Hogan, Lisa

Aleksoska, Elena

van Raay, Leena

Liberatore, Gabriel T

Batchelor, Peter Egerton

Howells, David William

Journal Article

10.1038/jcbfm.2009.273

Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2 h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.

link

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2010; 30(4): 729-33

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism