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Title: Chronic administration of MK-801 and the NMDA receptor: further evidence for reduced sensitivity of the primary acceptor site from studies with the cortical wedge preparation.
Austin Authors: Beart, P M;Lodge, D
Affiliation: University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-May-1990
Publication information: The Journal of Pharmacy and Pharmacology; 42(5): 354-5
Abstract: Cortical slices removed from rats pre-treated with MK-901 0.5 mg kg-1 twice a day for 7 days had reduced responses to N-methyl-D-aspartate (NMDA) relative to quisqualate and glutamate compared with control animals. Potencies of competitive (CPMP) and non-competitive (ketamine) NMDA antagonists appeared unchanged. These changes are consistent with a reduced density of NMDA receptors.
Gov't Doc #: 1976785
Journal: The Journal of pharmacy and pharmacology
Type: Journal Article
Subjects: Animals
Binding, Competitive.drug effects
Cerebral Cortex.drug effects.metabolism
Dizocilpine Maleate.pharmacology
In Vitro Techniques
Quisqualic Acid.pharmacology
Rats, Inbred Strains
Receptors, N-Methyl-D-Aspartate.metabolism
Appears in Collections:Journal articles

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