Austin Health

Title
Chronic administration of MK-801 and the NMDA receptor: further evidence for reduced sensitivity of the primary acceptor site from studies with the cortical wedge preparation.
Publication Date
1990-05-01
Author(s)
Beart, P M
Lodge, D
Type of document
Journal Article
Abstract
Cortical slices removed from rats pre-treated with MK-901 0.5 mg kg-1 twice a day for 7 days had reduced responses to N-methyl-D-aspartate (NMDA) relative to quisqualate and glutamate compared with control animals. Potencies of competitive (CPMP) and non-competitive (ketamine) NMDA antagonists appeared unchanged. These changes are consistent with a reduced density of NMDA receptors.
Link
link
Citation
The Journal of Pharmacy and Pharmacology; 42(5): 354-5
Jornal Title
The Journal of pharmacy and pharmacology

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