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Title: Identification of four different CD46 (MCP) molecules with anti-peptide antibodies.
Austin Authors: Purcell, D F;Jonstone, R W;McKenzie, Ian F C
Affiliation: Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 31-Oct-1991
Publication information: Biochemical and Biophysical Research Communications; 180(2): 1091-7
Abstract: Four protein isoforms of the human CD46 molecule (MCP) have been identified using rabbit antisera against synthetic peptides corresponding to predicted cytoplasmic carboxyl-terminal sequences. Two different cytoplasmic tails, CD46 CYT 1 and CD46 CYT 2, were detected in CD46 molecules isolated from almost every cell type examined. Bands of 56 and 66 kDa were obtained from SDS-PAGE analyses of various cell types with both CYT 1 and CYT 2 antisera, which indicated that the size polymorphism of the CD46 molecule is not due to variations in the cytoplasmic tail and that each species contained two different sized molecules.
Gov't Doc #: 1953714
Journal: Biochemical and biophysical research communications
Type: Journal Article
Subjects: Amino Acid Sequence
Antigen-Antibody Complex
Antigens, CD.analysis.genetics.immunology
Antigens, CD46
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Membrane Glycoproteins.analysis.genetics.immunology
Molecular Sequence Data
Peptides.chemical synthesis.immunology
Appears in Collections:Journal articles

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