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Title: | Identification of four different CD46 (MCP) molecules with anti-peptide antibodies. | Austin Authors: | Purcell, D F;Jonstone, R W;McKenzie, Ian F C | Affiliation: | Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 31-Oct-1991 | Publication information: | Biochemical and Biophysical Research Communications; 180(2): 1091-7 | Abstract: | Four protein isoforms of the human CD46 molecule (MCP) have been identified using rabbit antisera against synthetic peptides corresponding to predicted cytoplasmic carboxyl-terminal sequences. Two different cytoplasmic tails, CD46 CYT 1 and CD46 CYT 2, were detected in CD46 molecules isolated from almost every cell type examined. Bands of 56 and 66 kDa were obtained from SDS-PAGE analyses of various cell types with both CYT 1 and CYT 2 antisera, which indicated that the size polymorphism of the CD46 molecule is not due to variations in the cytoplasmic tail and that each species contained two different sized molecules. | Gov't Doc #: | 1953714 | URI: | http://ahro.austin.org.au/austinjspui/handle/1/10842 | Journal: | Biochemical and biophysical research communications | URL: | https://pubmed.ncbi.nlm.nih.gov/1953714 | Type: | Journal Article | Subjects: | Amino Acid Sequence Animals Antibodies Antigen-Antibody Complex Antigens, CD.analysis.genetics.immunology Antigens, CD46 Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Humans Membrane Glycoproteins.analysis.genetics.immunology Molecular Sequence Data Peptides.chemical synthesis.immunology Rabbits.immunology |
Appears in Collections: | Journal articles |
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