Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10782
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dc.contributor.authorHardikar, Winitaen
dc.contributor.authorKansal, Shivanien
dc.contributor.authorOude Elferink, Ronald P Jen
dc.contributor.authorAngus, Peter Wen
dc.date.accessioned2015-05-16T00:20:47Z
dc.date.available2015-05-16T00:20:47Z
dc.date.issued2009-03-07en
dc.identifier.citationWorld Journal of Gastroenterology; 15(9): 1126-9en
dc.identifier.govdoc19266607en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10782en
dc.description.abstractPruritus with abnormal liver function tests is the classical presentation of intrahepatic cholestasis of pregnancy (ICP), a condition associated with significant fetal complications. Although the etiology of ICP is unclear in many cases, certain features of the clinical presentation should alert the practitioner to the possibility of an underlying metabolic defect, which may not only affect subsequent pregnancies, but may be an indicator of more serious subsequent liver disease. We report a kindred of Anglo-Celtic descent, among whom many members present with ICP, gallstones or cholestasis related to use of oral contraception. Genetic studies revealed a novel mutation in the ABCB4 gene, which codes for a phospholipid transport protein. The clinical significance of this mutation and the importance of identifying such patients are discussed.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherCholestasis, Intrahepatic.epidemiology.geneticsen
dc.subject.otherDNA.geneticsen
dc.subject.otherEthnic Groups.geneticsen
dc.subject.otherFemaleen
dc.subject.otherFetal Diseases.diagnosisen
dc.subject.otherHumansen
dc.subject.otherLiver Function Testsen
dc.subject.otherMaleen
dc.subject.otherP-Glycoproteins.geneticsen
dc.subject.otherPedigreeen
dc.subject.otherPregnancyen
dc.subject.otherPregnancy Complications.epidemiology.geneticsen
dc.titleIntrahepatic cholestasis of pregnancy: when should you look further?en
dc.typeJournal Articleen
dc.identifier.journaltitleWorld Journal of Gastroenterologyen
dc.identifier.affiliationVictorian Liver Transplant Unit, Austin Hospital, Melbourne 3084, Australiaen
dc.description.pages1126-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19266607en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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