Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10734
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dc.contributor.authorReade, Michael Cen
dc.contributor.authorAngus, Derek Cen
dc.date.accessioned2015-05-16T00:16:43Z
dc.date.available2015-05-16T00:16:43Z
dc.date.issued2009-01-01en
dc.identifier.citationCritical Care Medicine; 37(1 Suppl): S1-9en
dc.identifier.govdoc19104206en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10734en
dc.description.abstractIntensivists have been remarkably successful in using randomized controlled trials to assess aspects of current practice. Unfortunately, this success has not been mirrored in trials of new pharmacotherapy, despite convincing pathophysiological rationales and encouraging preliminary studies. Misunderstandings of biological processes and flawed early clinical studies have led to the almost universal failure of fundamentally new treatments subjected to large phase III trials, despite their sound methodology. Compounding these problems is the tendency for new approaches to be either implemented widely on the basis of relatively poor studies or ignored despite strong supporting evidence. Having mastered the principles of evidence-based medicine in assessing existing therapy, intensivists have established a strong foundation. Critical care medicine must now embrace the challenge of translating a more solid understanding of basic disease mechanisms into widely implemented treatments.en
dc.language.isoenen
dc.subject.otherBiomedical Research.organization & administrationen
dc.subject.otherClinical Trials as Topicen
dc.subject.otherCritical Careen
dc.subject.otherEvidence-Based Medicineen
dc.subject.otherHumansen
dc.subject.otherResearch Designen
dc.subject.otherResearch Support as Topicen
dc.titleThe clinical research enterprise in critical care: what's right, what's wrong, and what's ahead?en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Care Medicineen
dc.identifier.affiliationDepartment of Intensive Care Medicine (MCR), Austin Hospital, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.doi10.1097/CCM.0b013e318192074cen
dc.description.pagesS1-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19104206en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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