Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10703
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dc.contributor.authorBatchelor, Peter Egertonen
dc.contributor.authorTan, Simonen
dc.contributor.authorWills, Taryn Een
dc.contributor.authorPorritt, Michelle Jen
dc.contributor.authorHowells, David Williamen
dc.date.accessioned2015-05-16T00:14:23Z
dc.date.available2015-05-16T00:14:23Z
dc.date.issued2008-10-01en
dc.identifier.citationJournal of Neurotrauma; 25(10): 1217-25en
dc.identifier.govdoc18986223en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10703en
dc.description.abstractInflammation in the CNS predominantly involves microglia and macrophages, and is believed to be a significant cause of secondary injury following trauma. This study compares the microglial and macrophage response in the rat brain and spinal cord following discrete mechanical injury to better appreciate the degree to which these cells could contribute to secondary damage in these areas. We find that, 1 week after injury, the microglial and macrophage response is significantly greater in the spinal cord compared to the brain. This is the case for injuries to both gray and white matter. In addition, we observed a greater inflammatory response in white matter compared to gray matter within both the brain and spinal cord. Because activated microglia and macrophages appear to be effectors of secondary damage, a greater degree of inflammation in the spinal cord is likely to result in more extensive secondary damage. Tissue saving strategies utilizing anti-inflammatory treatments may therefore be more useful in traumatic spinal cord than brain injury.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAnti-Inflammatory Agents.pharmacology.therapeutic useen
dc.subject.otherAntigens, CD11b.analysis.metabolismen
dc.subject.otherBiological Markers.analysis.metabolismen
dc.subject.otherBrain.immunology.pathology.physiopathologyen
dc.subject.otherBrain Injuries.immunology.pathology.physiopathologyen
dc.subject.otherDisease Models, Animalen
dc.subject.otherEncephalitis.immunology.pathology.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherGliosis.immunology.pathology.physiopathologyen
dc.subject.otherMacrophages.immunology.pathologyen
dc.subject.otherMicroglia.immunology.pathologyen
dc.subject.otherMyelitis.immunology.pathology.physiopathologyen
dc.subject.otherNerve Fibers, Myelinated.immunology.pathologyen
dc.subject.otherNeuroprotective Agents.pharmacology.therapeutic useen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred F344en
dc.subject.otherSpinal Cord.immunology.pathology.physiopathologyen
dc.subject.otherTime Factorsen
dc.titleComparison of inflammation in the brain and spinal cord following mechanical injury.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of neurotraumaen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Health, Victoria, Australiaen
dc.identifier.doi10.1089/neu.2007.0308en
dc.description.pages1217-25en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18986223en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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