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Title: Comparison of inflammation in the brain and spinal cord following mechanical injury.
Austin Authors: Batchelor, Peter Egerton;Tan, Simon;Wills, Taryn E;Porritt, Michelle J;Howells, David William
Affiliation: Department of Medicine, University of Melbourne, Austin Health, Victoria, Australia
Issue Date: 1-Oct-2008
Publication information: Journal of Neurotrauma; 25(10): 1217-25
Abstract: Inflammation in the CNS predominantly involves microglia and macrophages, and is believed to be a significant cause of secondary injury following trauma. This study compares the microglial and macrophage response in the rat brain and spinal cord following discrete mechanical injury to better appreciate the degree to which these cells could contribute to secondary damage in these areas. We find that, 1 week after injury, the microglial and macrophage response is significantly greater in the spinal cord compared to the brain. This is the case for injuries to both gray and white matter. In addition, we observed a greater inflammatory response in white matter compared to gray matter within both the brain and spinal cord. Because activated microglia and macrophages appear to be effectors of secondary damage, a greater degree of inflammation in the spinal cord is likely to result in more extensive secondary damage. Tissue saving strategies utilizing anti-inflammatory treatments may therefore be more useful in traumatic spinal cord than brain injury.
Gov't Doc #: 18986223
DOI: 10.1089/neu.2007.0308
Journal: Journal of neurotrauma
Type: Journal Article
Subjects: Animals
Anti-Inflammatory Agents.pharmacology.therapeutic use
Antigens, CD11b.analysis.metabolism
Biological Markers.analysis.metabolism
Brain Injuries.immunology.pathology.physiopathology
Disease Models, Animal
Nerve Fibers, Myelinated.immunology.pathology
Neuroprotective Agents.pharmacology.therapeutic use
Rats, Inbred F344
Spinal Cord.immunology.pathology.physiopathology
Time Factors
Appears in Collections:Journal articles

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