Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10679
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dc.contributor.authorCzuba, M Aen
dc.contributor.authorMorgan, Denis Jen
dc.contributor.authorChing, M Sen
dc.contributor.authorMihaly, G Wen
dc.contributor.authorGhabrial, Hanyen
dc.contributor.authorHardy, Kenneth Johnen
dc.contributor.authorSmallwood, R Aen
dc.date.accessioned2015-05-16T00:12:35Z
dc.date.available2015-05-16T00:12:35Z
dc.date.issued1991-05-01en
dc.identifier.citationJournal of Pharmaceutical Sciences; 80(5): 445-8en
dc.identifier.govdoc1880724en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10679en
dc.description.abstractThe disposition of the diastereoisomers quinine and quinidine was investigated in the near-term pregnant ewe. Five sheep were administered quinine and quinidine separately in random order by a combination of bolus and 30-h iv infusion. On a subsequent occasion, four of the five sheep were also administered the two drugs simultaneously. After separate dosage, systemic clearance of quinine tended to be greater than that of quinidine (714 +/- 299 versus 422 +/- 146 mL/min, p = 0.08). Maternal renal clearance exhibited no stereoselectivity and represented less than 2% of total clearance. Simultaneous administration did not alter the disposition of either drug in the mother. After separate dosage, fetal total concentrations (Cf) of quinine and quinidine were substantially lower than maternal total concentrations, as reflected in Cf:Cm ratios of 0.15 +/- 0.06 versus 0.10 +/- 0.08, respectively. Similarly, fetal unbound concentrations (Cfu) were substantially lower than maternal unbound concentrations (Cmu; Cfu/Cmu = 0.46 +/- 0.09 for quinine and 0.23 +/- 0.09 for quinidine). This indicates the presence of fetal elimination of both isomers. Fetal renal clearances of quinine and quinidine were similar (0.34 +/- 0.24 mL/min versus 0.38 +/- 0.24 mL/min) and less than that of endogenous creatinine, indicating the absence of net renal tubular secretion. After simultaneous dosage of quinine and quinidine, Cf:Cm (0.48 +/- 0.24 and 0.31 +/- 0.19, respectively) and Cfu:Cmu (0.73 +/- 0.14 and 0.52 +/- 0.20, respectively) were greater than for separate dosages. Fetal renal clearance of both drugs was unchanged, suggesting that the higher Cfu:Cmu ratios after simultaneous dosage were due to mutual inhibition of the fetal metabolism of these drugs.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherChromatography, High Pressure Liquiden
dc.subject.otherCreatinine.metabolismen
dc.subject.otherFemaleen
dc.subject.otherFetus.metabolismen
dc.subject.otherPlacenta.metabolismen
dc.subject.otherPregnancyen
dc.subject.otherQuinidine.pharmacokineticsen
dc.subject.otherQuinine.pharmacokineticsen
dc.subject.otherSheep.metabolismen
dc.subject.otherStereoisomerismen
dc.titleDisposition of the diastereoisomers quinine and quinidine in the ovine fetus.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of pharmaceutical sciencesen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin Hospital, Australiaen
dc.description.pages445-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1880724en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
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