Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10651
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHaase, Michaelen
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorStory, David Aen
dc.contributor.authorDavenport, Piersen
dc.contributor.authorHaase-Fielitz, Anjaen
dc.date.accessioned2015-05-16T00:10:28Z
dc.date.available2015-05-16T00:10:28Z
dc.date.issued2008-08-01en
dc.identifier.citationCritical Care 2008; 12(4): R96en
dc.identifier.govdoc18673539en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10651en
dc.description.abstractUrinary interleukin-18 (IL-18) measured during the immediate postoperative period could be a promising predictor of acute kidney injury following adult cardiac surgery.In a single-centre prospective observational cohort study, we enrolled 100 adult cardiac surgical patients undergoing cardiopulmonary bypass at a tertiary hospital. We measured the urinary concentration of IL-18 and creatinine preoperatively, on arrival in the intensive care unit, and 24 hours postoperatively. We assessed urinary IL-18 concentration and urinary IL-18/urinary creatinine ratio in relation to the postoperative development of acute kidney injury defined as an increase in serum creatinine of greater than 50% from preoperative to postoperative peak value within 48 hours after surgery.Twenty patients developed acute kidney injury. On arrival in the intensive care unit and at 24 hours postoperatively, urinary IL-18 (median [interquartile range]) was not different in patients who subsequently developed acute kidney injury compared with those who did not: on arrival in the intensive care unit (168 [717] versus 104 [256] pg/mL; P = 0.70) and at 24 hours (195 [483] versus 165 [246] pg/mL; P = 0.47). On arrival in the intensive care unit (area under the curve for the receiver operating characteristic curve [AUC-ROCC] 0.53, 95% confidence interval [CI] 0.38 to 0.68; P = 0.70) and at 24 hours postoperatively (AUC-ROCC 0.55, 95% CI 0.40 to 0.71; P = 0.48), urinary IL-18 was not better than chance in predicting acute kidney injury. All findings were confirmed when urinary IL-18 was adjusted for urinary creatinine. Urinary IL-18 correlated with duration of cardiopulmonary bypass (P < 0.001).In adults, early postoperative measurement of urinary IL-18 appears not to be valuable in identifying patients who develop acute kidney injury after cardiac surgery, but rather represents a nonspecific marker of cardiopulmonary bypass-associated systemic inflammation.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.diagnosis.etiology.urineen
dc.subject.otherAgeden
dc.subject.otherBiological Markers.urineen
dc.subject.otherCardiac Surgical Procedures.adverse effectsen
dc.subject.otherCohort Studiesen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherInterleukin-18.urineen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPostoperative Complications.diagnosis.etiology.urineen
dc.subject.otherPredictive Value of Testsen
dc.subject.otherProspective Studiesen
dc.titleUrinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: a prospective observational cohort study.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Careen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Melbourne, 145 Studley Rd, Heidelberg 3084, Australiaen
dc.identifier.doi10.1186/cc6972en
dc.description.pagesR96en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18673539en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptAnaesthesia-
Appears in Collections:Journal articles
Files in This Item:
File Description SizeFormat 
18673539.pdf240.38 kBAdobe PDFThumbnail
View/Open
Show simple item record

Page view(s)

20
checked on Mar 28, 2024

Download(s)

68
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.