Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10641
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAger, Eleanor Ien
dc.contributor.authorNeo, Jaclynen
dc.contributor.authorChristophi, Christopheren
dc.date.accessioned2015-05-16T00:09:43Z
dc.date.available2015-05-16T00:09:43Z
dc.date.issued2008-07-16en
dc.identifier.citationCarcinogenesis 2008; 29(9): 1675-84en
dc.identifier.govdoc18632755en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10641en
dc.description.abstractThe renin-angiotensin system (RAS) is usually associated with its systemic action on cardiovascular homoeostasis. However, recent studies suggest that at a local tissue level, the RAS influences tumour growth. The potential of the RAS as a target for cancer treatment and the suggested underlying mechanisms of its paracrine effects are reviewed here. These include modulation of angiogenesis, cellular proliferation, immune responses and extracellular matrix formation. Knowledge of the RAS has increased dramatically in recent years with the discovery of new enzymes, peptides and feedback mechanisms. The local RAS appears to influence tumour growth and metastases and there is evidence of tissue- and tumour-specific differences. Recent experimental studies provide strong evidence that drugs that inhibit the RAS have the potential to reduce cancer risk or retard tumour growth and metastases. Manipulation of the RAS may, therefore, provide a safe and inexpensive anticancer strategy.en
dc.language.isoenen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.therapeutic useen
dc.subject.otherAnimalsen
dc.subject.otherHumansen
dc.subject.otherNeoplasms.metabolism.pathologyen
dc.subject.otherRenin-Angiotensin System.physiologyen
dc.titleThe renin-angiotensin system and malignancy.en
dc.typeJournal Articleen
dc.identifier.journaltitleCarcinogenesisen
dc.identifier.affiliationDepartment of Surgery, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1093/carcin/bgn171en
dc.description.pages1675-84en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18632755en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptSurgery-
crisitem.author.deptHepatopancreatobiliary Surgery-
Appears in Collections:Journal articles
Show simple item record

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.